WEE1 and TP53 synthetic lethal interaction mechanism (by Figdraw)

WEE1 and TP53 synthetic lethal interaction mechanism (by Figdraw). (A) In cancer cells with TP53 mutation, when SSB occurs, ATR can activate CHK1, and the activated CHK1 can activate WEE1, thereby inhibiting the activity of CDK1 and CDK2, arresting the cell cycle in G1/S and G2/M phases, and obtaining more time for cells to repair DNA damage. (B) After using WEE1 inhibitors in cancer cells with TP53 mutations, the blocking effect disappears, and the cells will die due to the mitotic catastrophe. Yellow lightning indicates cell cycle arrest. The red arrow indicates that this pathway is activated. The grey arrow indicates that the pathway is inactivated.
WEE1 and TP53 synthetic lethal interaction mechanism (by Figdraw)
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Publication

Unleashing the Power of Synthetic Lethality: Augmenting Treatment Efficacy through Synergistic Integration with Chemotherapy Drugs (2023) Yajing Du, et al. Pharmaceutics. 2023 Oct;15(10). Figure: F5.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates SSB SSB ncbigene_symbol SSB 6741
Homo sapiens Primates ATM ATM ncbigene_symbol ATM 472
Homo sapiens Primates ATR ATR ncbigene_symbol ATR 545
Homo sapiens Primates ATR ATR ncbigene_synonym ANTXR1 84168
Homo sapiens Primates ATR ATR ncbigene_synonym MMAB 326625
Homo sapiens Primates ATR ATR ncbigene_synonym SERPINA2 390502
Homo sapiens Primates Wee1 WEE1 ncbigene_symbol WEE1 7465
Homo sapiens Primates p53 P53 ncbigene_synonym TP53 7157
Homo sapiens Primates p53 P53 famplex_relations TP63 8626
Homo sapiens Primates p53 P53 famplex_relations TP73 7161
Homo sapiens Primates CHK1 CHK1 ncbigene_synonym CHEK1 1111
Homo sapiens Primates p21 P21 ncbigene_synonym CDKN1A 1026
Homo sapiens Primates p21 P21 ncbigene_synonym TCEAL1 9338
Homo sapiens Primates p21 P21 ncbigene_synonym NSG1 27065
Homo sapiens Primates p21 P21 ncbigene_synonym H3P16 644914
Homo sapiens Primates CDK2 CDK2 ncbigene_symbol CDK2 1017
Homo sapiens Primates CDK1 CDK1 ncbigene_symbol CDK1 983
Homo sapiens Primates G2 G2 ncbigene_synonym WARS1 7453

Chemical mentions

Word Match MeSH Name ChEBI
inhibitor inhibitor inhibitor chebi:35222

Disease mentions

Word Match MeSH Name DOID