SBP effects on BMP2-Smad1/5/9-Runx2 signaling pathway
Schematic representation of SBP effects on BMP2-Smad1/5/9-Runx2 signaling pathway. BMP (Bone morphogenetic protein2), BMPR (BMP receptor), RUNX2 (Runt-related transcription factor 2), OPN (Osteopontin), OCN (Osteocalcin), SPARC (Secreted protein acidic and cysteine-rich), ALP (Alkaline phosphatase), COL-I (Type I collagen).
Publication
Sword Bean (Canavalia gladiata) Pods Induce Differentiation in MC3T3-E1 Osteoblast Cells by Activating the BMP2/SMAD/RUNX2 Pathway (2023) Yu Jin Hwang, et al. Nutrients. 2023 Oct;15(20). Figure: F7.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Homo sapiens | Primates | bean | BEAN | ncbigene_synonym | BEAN1 | 146227 |
| Homo sapiens | Primates | SMAD1 | SMAD1 | ncbigene_symbol | SMAD1 | 4086 |
| Homo sapiens | Primates | SMAD1 | SMAD1 | ncbigene_synonym | GARS1 | 2617 |
| Homo sapiens | Primates | SMAD1/5/9 | SMAD5 | ncbigene_symbol | SMAD5 | 4090 |
| Homo sapiens | Primates | SMAD1/5/9 | SMAD9 | ncbigene_symbol | SMAD9 | 4093 |
| Homo sapiens | Primates | ALP | ALP | ncbigene_synonym | ALPP | 250 |
| Homo sapiens | Primates | ALP | ALP | ncbigene_synonym | ATHS | 470 |
| Homo sapiens | Primates | ALP | ALP | ncbigene_synonym | SLPI | 6590 |
| Homo sapiens | Primates | ALP | ALP | ncbigene_synonym | CCL27 | 10850 |
| Homo sapiens | Primates | ALP | ALP | ncbigene_synonym | ATRNL1 | 26033 |
| Homo sapiens | Primates | ALP | ALP | ncbigene_synonym | PDLIM3 | 27295 |
| Homo sapiens | Primates | ALP | ALP | ncbigene_synonym | NAT10 | 55226 |
| Homo sapiens | Primates | ALP | ALP | ncbigene_synonym | ASRGL1 | 80150 |
| Homo sapiens | Primates | BMP2 | BMP2 | ncbigene_symbol | BMP2 | 650 |
| Homo sapiens | Primates | COL1 | COL1 | famplex_relations | COL1A1 | 1277 |
| Homo sapiens | Primates | COL1 | COL1 | famplex_relations | COL1A2 | 1278 |
| Homo sapiens | Primates | RUNX2 | RUNX2 | ncbigene_symbol | RUNX2 | 860 |
| Homo sapiens | Primates | OPN | OPN | ncbigene_synonym | SPP1 | 6696 |
| Homo sapiens | Primates | OCN | OCN | ncbigene_synonym | BGLAP | 632 |
| Homo sapiens | Primates | SPARC | SPARC | ncbigene_symbol | SPARC | 6678 |
| Homo sapiens | Primates | Collagen | COLLAGEN | famplex_relations | COL6A1 | 1291 |
| Homo sapiens | Primates | Collagen | COLLAGEN | famplex_relations | COL6A2 | 1292 |
| Homo sapiens | Primates | Collagen | COLLAGEN | famplex_relations | COL6A3 | 1293 |
| Homo sapiens | Primates | Collagen | COLLAGEN | famplex_relations | COL6A5 | 256076 |
| Homo sapiens | Primates | Collagen | COLLAGEN | famplex_relations | COL6A6 | 131873 |
| Homo sapiens | Primates | Collagen | COLLAGEN | famplex_relations | COL7A1 | 1294 |
| Homo sapiens | Primates | Collagen | COLLAGEN | famplex_relations | COL8A1 | 1295 |
| Homo sapiens | Primates | Collagen | COLLAGEN | famplex_relations | COL8A2 | 1296 |
| Homo sapiens | Primates | Collagen | COLLAGEN | famplex_relations | COL9A1 | 1297 |
| Homo sapiens | Primates | Collagen | COLLAGEN | famplex_relations | COL9A2 | 1298 |
| Homo sapiens | Primates | Collagen | COLLAGEN | famplex_relations | COL9A3 | 1299 |
| Homo sapiens | Primates | Collagen | COLLAGEN | famplex_relations | COL10A1 | 1300 |
| Homo sapiens | Primates | Collagen | COLLAGEN | famplex_relations | COL11A1 | 1301 |
| Homo sapiens | Primates | Collagen | COLLAGEN | famplex_relations | COL11A2 | 1302 |
| Homo sapiens | Primates | Collagen | COLLAGEN | famplex_relations | COL12A1 | 1303 |
| Homo sapiens | Primates | Collagen | COLLAGEN | famplex_relations | COL13A1 | 1305 |
| Homo sapiens | Primates | Collagen | COLLAGEN | famplex_relations | COL14A1 | 7373 |
| Homo sapiens | Primates | Collagen | COLLAGEN | famplex_relations | COL15A1 | 1306 |
| Homo sapiens | Primates | Collagen | COLLAGEN | famplex_relations | COL16A1 | 1307 |
| Homo sapiens | Primates | Collagen | COLLAGEN | famplex_relations | COL17A1 | 1308 |
| Homo sapiens | Primates | Collagen | COLLAGEN | famplex_relations | COL18A1 | 80781 |
| Homo sapiens | Primates | Collagen | COLLAGEN | famplex_relations | COL19A1 | 1310 |
| Homo sapiens | Primates | Collagen | COLLAGEN | famplex_relations | COL20A1 | 57642 |
| Homo sapiens | Primates | Collagen | COLLAGEN | famplex_relations | COL21A1 | 81578 |
| Homo sapiens | Primates | Collagen | COLLAGEN | famplex_relations | COL22A1 | 169044 |
| Homo sapiens | Primates | Collagen | COLLAGEN | famplex_relations | COL23A1 | 91522 |
| Homo sapiens | Primates | Collagen | COLLAGEN | famplex_relations | COL24A1 | 255631 |
| Homo sapiens | Primates | Collagen | COLLAGEN | famplex_relations | COL25A1 | 84570 |
| Homo sapiens | Primates | Collagen | COLLAGEN | famplex_relations | COL26A1 | 136227 |
| Homo sapiens | Primates | Collagen | COLLAGEN | famplex_relations | COL27A1 | 85301 |
| Homo sapiens | Primates | Collagen | COLLAGEN | famplex_relations | COL28A1 | 340267 |
| Homo sapiens | Primates | Collagen | COLLAGEN | famplex_relations | COL4A1 | 1282 |
| Homo sapiens | Primates | Collagen | COLLAGEN | famplex_relations | COL4A2 | 1284 |
| Homo sapiens | Primates | Collagen | COLLAGEN | famplex_relations | COL4A3 | 1285 |
| Homo sapiens | Primates | Collagen | COLLAGEN | famplex_relations | COL4A4 | 1286 |
| Homo sapiens | Primates | Collagen | COLLAGEN | famplex_relations | COL4A5 | 1287 |
| Homo sapiens | Primates | Collagen | COLLAGEN | famplex_relations | COL4A6 | 1288 |
| Homo sapiens | Primates | Collagen | COLLAGEN | famplex_relations | COL5A1 | 1289 |
| Homo sapiens | Primates | Collagen | COLLAGEN | famplex_relations | COL5A2 | 1290 |
| Homo sapiens | Primates | Collagen | COLLAGEN | famplex_relations | COL5A3 | 50509 |
| Word | Match | MeSH | Name | ChEBI |
|---|---|---|---|---|
| Collagen | Collagen | chebi:3815 |
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|