Lipid metabolism

Overview of lipid metabolism. Dietary carbohydrates and lipids are major contributors of fatty acids. Carbohydrates may be converted into triglycerides via the G3P pathway or fatty acids via DNL through the mitochondrial tricarboxylic acid cycle. The latter is regulated by both the ChREBP and SREBP1c signalling pathways. Fatty acids can be stored in cytoplasmic lipid droplets until required or be oxidised for removal. β-oxidation of lipids can occur in the mitochondria or peroxisomes and is mainly regulated by the PPARα signalling pathway. This figure was created with BioRender.com.
Lipid metabolism
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Publication

Gene Variants Implicated in Steatotic Liver Disease: Opportunities for Diagnostics and Therapeutics (2023) Gary Huang, et al. Biomedicines. 2023 Oct;11(10). Figure: F3.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates GLUT2 GLUT2 ncbigene_synonym SLC2A2 6514
Homo sapiens Primates GPAT GPAT ncbigene_synonym PPAT 5471
Homo sapiens Primates GPAT GPAT ncbigene_synonym GPAM 57678
Homo sapiens Primates DGAT DGAT ncbigene_synonym DGAT1 8694
Homo sapiens Primates ChREBP CHREBP ncbigene_synonym MLXIPL 51085
Homo sapiens Primates NF-kB NF-KB ncbigene_synonym NFKB1 4790
Homo sapiens Primates CD36 CD36 ncbigene_symbol CD36 948
Homo sapiens Primates FATP FATP ncbigene_synonym SLC27A1 376497
Homo sapiens Primates PPARA PPARA ncbigene_symbol PPARA 5465
Homo sapiens Primates IL-6 IL-6 ncbigene_synonym IL6 3569
Homo sapiens Primates TNFα TNF ncbigene_symbol TNF 7124
Homo sapiens Primates LPA LPA ncbigene_symbol LPA 4018
Homo sapiens Primates AOX AOX ncbigene_synonym ACOX1 51
Homo sapiens Primates ACLY ACLY ncbigene_symbol ACLY 47
Homo sapiens Primates MGAT MGAT ncbigene_synonym MGAT1 4245
Homo sapiens Primates MGAT MGAT famplex_relations MGAT2 4247
Homo sapiens Primates MGAT MGAT famplex_relations MGAT3 4248
Homo sapiens Primates MGAT MGAT famplex_relations MGAT4A 11320
Homo sapiens Primates MGAT MGAT famplex_relations MGAT4B 11282
Homo sapiens Primates MGAT MGAT famplex_relations MGAT4C 25834
Homo sapiens Primates MGAT MGAT famplex_relations MGAT4D 152586
Homo sapiens Primates MGAT MGAT famplex_relations MGAT5 4249
Homo sapiens Primates MGAT MGAT famplex_relations MGAT5B 146664
Homo sapiens Primates ACC1 ACC1 ncbigene_synonym ACACA 31
Homo sapiens Primates ACC1 ACC1 ncbigene_synonym BCL2A1 597
Homo sapiens Primates FASN FASN ncbigene_symbol FASN 2194
Homo sapiens Primates ELOVL6 ELOVL6 ncbigene_symbol ELOVL6 79071
Homo sapiens Primates TG TG ncbigene_symbol TG 7038
Homo sapiens Primates SCD1 SCD1 ncbigene_synonym SCD 6319

Chemical mentions

Word Match MeSH Name ChEBI
Carbohydrates carbohydrates carbohydrates chebi:16646
Fatty Acids fatty acids fatty acids chebi:35366
Nucleus nucleus nucleus chebi:33252
NOX NOX 3-[(2S)-1-methyl-1-oxidopyrrolidin-2-yl]pyridine chebi:142659
Acetyl-CoA acetyl-CoA 3'-phosphonatoadenosine 5'-(3-{(3R)-4-[(3-{[2-(acetylsulfanyl)ethyl]amino}-3-oxopropyl)amino]-3-hydroxy-2,2-dimethyl-4-oxobutyl} diphosphate) chebi:57288
ROS ROS chebi:26523
Pyruvate pyruvate pyruvate chebi:15361
Citrate citrate chebi:133748
Acetyl-CoA acetyl-CoA 3'-phosphonatoadenosine 5'-(3-{(3R)-4-[(3-{[2-(acetylsulfanyl)ethyl]amino}-3-oxopropyl)amino]-3-hydroxy-2,2-dimethyl-4-oxobutyl} diphosphate) chebi:57288
Malonyl-CoA malonyl-CoA 3'-phosphonatoadenosine 5'-{3-[(3R)-4-{[3-({2-[(3-carboxylatoacetyl)sulfanyl]ethyl}amino)-3-oxopropyl]amino}-3-hydroxy-2,2-dimethyl-4-oxobutyl] diphosphate} chebi:57384

Disease mentions

Word Match MeSH Name DOID