Molecular pathways in Hep3B cell line

Molecular pathways in Hep3B cell line. KEGG pathway diagrams show the enrichment of metabolic and signaling pathways in treated vs. untreated HCC cancer cell line (Hep3B). Relative gene expressions derived from RNAseq analyses are depicted in pathways with red indicating up- and green indicating downregulation, respectively. (i) KEGG pathway for hepatocellular carcinoma. (ii) KEGG pathway for autophagy. (iii) KEGG pathway for pathways in cancer. (iv) KEGG pathway for mitophagy. (v) KEGG pathway for oxidative phosphorylation. (vi) KEGG pathway for TNF signaling pathway. (vii) KEGG pathway for NF-Kappa B signaling pathway. (viii) KEGG pathway for glutathione metabolism.
Molecular pathways in Hep3B cell line
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Publication

Normalization of the ATP1A1 Signalosome Rescinds Epigenetic Modifications and Induces Cell Autophagy in Hepatocellular Carcinoma † (2023) Pradeep Kumar Rajan, et al. Cells. 2023 Oct;12(19):2367. Figure: F7.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates Hep HEP ncbigene_synonym EPHB6 2051
Homo sapiens Primates Hep HEP ncbigene_synonym DNLZ 728489
Homo sapiens Primates PLC PLC ncbigene_synonym HSPG2 3339
Homo sapiens Primates PLC PLC famplex_relations PLCE1 51196
Homo sapiens Primates PLC PLC famplex_relations PLCZ1 89869
Homo sapiens Primates PLC PLC famplex_relations PLCB1 23236
Homo sapiens Primates PLC PLC famplex_relations PLCB2 5330
Homo sapiens Primates PLC PLC famplex_relations PLCB3 5331
Homo sapiens Primates PLC PLC famplex_relations PLCB4 5332
Homo sapiens Primates PLC PLC famplex_relations PLCD1 5333
Homo sapiens Primates PLC PLC famplex_relations PLCD3 113026
Homo sapiens Primates PLC PLC famplex_relations PLCD4 84812
Homo sapiens Primates PLC PLC famplex_relations PLCG1 5335
Homo sapiens Primates PLC PLC famplex_relations PLCG2 5336
Homo sapiens Primates TOB TOB ncbigene_synonym TOB1 10140
Homo sapiens Primates HCC HCC ncbigene_symbol HCC 619501
Homo sapiens Primates HCC HCC ncbigene_synonym HYCC1 84668
Homo sapiens Primates FZD FZD famplex_relations FZD1 8321
Homo sapiens Primates FZD FZD famplex_relations FZD10 11211
Homo sapiens Primates FZD FZD famplex_relations FZD2 2535
Homo sapiens Primates FZD FZD famplex_relations FZD3 7976
Homo sapiens Primates FZD FZD famplex_relations FZD4 8322
Homo sapiens Primates FZD FZD famplex_relations FZD5 7855
Homo sapiens Primates FZD FZD famplex_relations FZD6 8323
Homo sapiens Primates FZD FZD famplex_relations FZD7 8324
Homo sapiens Primates FZD FZD famplex_relations FZD8 8325
Homo sapiens Primates FZD FZD famplex_relations FZD9 8326
Homo sapiens Primates PKC PKC ncbigene_synonym PRRT2 112476
Homo sapiens Primates PKC PKC famplex_relations PRKCA 5578
Homo sapiens Primates PKC PKC famplex_relations PRKCB 5579
Homo sapiens Primates PKC PKC famplex_relations PRKCD 5580
Homo sapiens Primates PKC PKC famplex_relations PRKCE 5581
Homo sapiens Primates PKC PKC famplex_relations PRKCG 5582
Homo sapiens Primates PKC PKC famplex_relations PRKCH 5583
Homo sapiens Primates PKC PKC famplex_relations PRKCI 5584
Homo sapiens Primates PKC PKC famplex_relations PRKCQ 5588
Homo sapiens Primates PKC PKC famplex_relations PRKCZ 5590
Homo sapiens Primates PKC PKC famplex_relations PRKD3 23683
Homo sapiens Primates TOR TOR ncbigene_synonym RORC 6097
Homo sapiens Primates PTEN PTEN ncbigene_symbol PTEN 5728
Homo sapiens Primates MEK MEK ncbigene_synonym MAP2K7 5609
Homo sapiens Primates MEK MEK famplex_relations MAP2K1 5604
Homo sapiens Primates MEK MEK famplex_relations MAP2K2 5605
Homo sapiens Primates BAD BAD ncbigene_symbol BAD 572
Homo sapiens Primates CHA CHA ncbigene_synonym TCFL5 10732
Homo sapiens Primates p16 P16 ncbigene_synonym CDKN2A 1029
Homo sapiens Primates p16 P16 ncbigene_synonym H3P10 115482713
Homo sapiens Primates CDK4 CDK4 ncbigene_symbol CDK4 1019
Homo sapiens Primates GRP GRP ncbigene_symbol GRP 2922
Homo sapiens Primates GRP GRP ncbigene_synonym LSM4 25804
Homo sapiens Primates GRP GRP ncbigene_synonym LGALSL 29094
Homo sapiens Primates GRP GRP ncbigene_synonym UCMA 221044
Homo sapiens Primates HO-1 HO-1 ncbigene_synonym HMOX1 3162
Homo sapiens Primates Prof PROF ncbigene_synonym WDFY2 115825
Homo sapiens Primates MAFK MAFK ncbigene_symbol MAFK 7975
Homo sapiens Primates Prot PROT ncbigene_synonym SLC6A7 6534
Homo sapiens Primates MEX MEX ncbigene_synonym ZSWIM2 151112
Homo sapiens Primates HOF HOF ncbigene_synonym ZBTB20 26137
Homo sapiens Primates c-Met C-MET ncbigene_synonym MET 4233
Homo sapiens Primates Alt ALT ncbigene_synonym GPT 2875
Homo sapiens Primates Alt AIT ncbigene_synonym SLC5A8 160728
Homo sapiens Primates INS INS ncbigene_symbol INS 3630
Homo sapiens Primates AKT AKT ncbigene_synonym AKT1 207
Homo sapiens Primates AKT AKT famplex_relations AKT2 208
Homo sapiens Primates AKT AKT famplex_relations AKT3 10000
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAA1 5562
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAA2 5563
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAB1 5564
Homo sapiens Primates AMPK AMPK famplex_relations PRKAB2 5565
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG1 5571
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG2 51422
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG3 53632
Homo sapiens Primates BAF BAF ncbigene_synonym BANF1 8815
Homo sapiens Primates Cox COX ncbigene_synonym COX8A 1351
Homo sapiens Primates Cox COX ncbigene_synonym CPOX 1371
Homo sapiens Primates Cox COX ncbigene_synonym COX5A 9377
Homo sapiens Primates Cox COX famplex_relations COX5B 1329
Homo sapiens Primates Cox COX famplex_relations COX6C 1345
Homo sapiens Primates Cox COX famplex_relations COX7C 1350
Homo sapiens Primates Cox COX famplex_relations NA NaN
Homo sapiens Primates Cox COX famplex_relations COX4I1 1327
Homo sapiens Primates Cox COX famplex_relations COX4I2 84701
Homo sapiens Primates Cox COX famplex_relations COX6A1 1337
Homo sapiens Primates Cox COX famplex_relations COX6A2 1339
Homo sapiens Primates Cox COX famplex_relations COX6B1 1340
Homo sapiens Primates Cox COX famplex_relations COX6B2 125965
Homo sapiens Primates Cox COX famplex_relations COX7A1 1346
Homo sapiens Primates Cox COX famplex_relations COX7A2 1347
Homo sapiens Primates Cox COX famplex_relations COX7B 1349
Homo sapiens Primates Cox COX famplex_relations COX7B2 170712
Homo sapiens Primates Cox COX famplex_relations COX8C 341947
Homo sapiens Primates VMPI VMPI ncbigene_synonym ELMO2 63916
Homo sapiens Primates AMP AMP ncbigene_synonym APRT 353
Homo sapiens Primates AMP AMP ncbigene_synonym MFAP1 4236
Homo sapiens Primates ATP ATP ncbigene_synonym ATP8A2 51761
Homo sapiens Primates FLIP FLIP ncbigene_synonym CFLAR 8837
Homo sapiens Primates FLIP FLIP ncbigene_synonym FIRRM 55732
Homo sapiens Primates CTS CTS ncbigene_synonym TTR 7276
Homo sapiens Primates OTS OTS ncbigene_synonym OTSC1 5012
Homo sapiens Primates ATORS ATORS ncbigene_synonym SLC2A10 81031
Homo sapiens Primates LAMP LAMP ncbigene_synonym LSAMP 4045
Homo sapiens Primates LAMP LAMP ncbigene_synonym LAMP3 27074

Chemical mentions

Word Match MeSH Name ChEBI
MEK MEK butan-2-one chebi:28398
DHA DHA docosahexaenoic acid chebi:36005
DNA DNA deoxyribonucleic acids chebi:16991
GRP GRP glycyl-L-arginyl-L-proline chebi:144473
DNA DNA deoxyribonucleic acids chebi:16991
HOF HOF fluoridohydridooxygen chebi:47864
Alt Alt altro-hexose chebi:37708
INS Ins myo-inositol chebi:17268
PPA PPA (1R,2R)-2-amino-1-phenylpropan-1-ol chebi:8104

Disease mentions

Word Match MeSH Name DOID
CARCINOMA carcinoma carcinoma DOID:305
CARCINOMA carcinoma carcinoma DOID:305
Hepatitis hepatitis hepatitis DOID:2237
Hepatitis hepatitis hepatitis DOID:2237
HEPATOCELLULAR CARCINOMA hepatocellular carcinoma hepatocellular carcinoma DOID:684
HEPATOCELLULAR CARCINOMA hepatocellular carcinoma hepatocellular carcinoma DOID:684
Hepatitis B hepatitis B hepatitis B DOID:2043
Hepatitis C hepatitis C hepatitis C DOID:1883