Manner in which the studied product acts on the Wnt pathway in lung cancer
The manner in which the studied product acts on the Wnt pathway in lung cancer. Natural compounds and their derivatives inhibit the Wnt signaling pathway by reducing upstream activators such as SOX and COX-2, inhibiting Wnt ligands, inhibiting receptor phosphorylation such as Fzd, inhibiting Dvl, promoting destruction complex stabilization, and inhibiting β-catenin nuclear localization and TCF/LEF transcription factor activity.
Publication
Natural compounds: Wnt pathway inhibitors with therapeutic potential in lung cancer (2023) Xuetong Shen, et al. Front Pharmacol. 2023;14(1):1250893. Figure: F2.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Homo sapiens | Primates | TF | TF | ncbigene_symbol | TF | 7018 |
| Homo sapiens | Primates | ROS,COX | COX | ncbigene_synonym | COX8A | 1351 |
| Homo sapiens | Primates | ROS,COX | COX | ncbigene_synonym | CPOX | 1371 |
| Homo sapiens | Primates | ROS,COX | COX | ncbigene_synonym | COX5A | 9377 |
| Homo sapiens | Primates | ROS,COX | COX | famplex_relations | COX5B | 1329 |
| Homo sapiens | Primates | ROS,COX | COX | famplex_relations | COX6C | 1345 |
| Homo sapiens | Primates | ROS,COX | COX | famplex_relations | COX7C | 1350 |
| Homo sapiens | Primates | ROS,COX | COX | famplex_relations | NA | NaN |
| Homo sapiens | Primates | ROS,COX | COX | famplex_relations | COX4I1 | 1327 |
| Homo sapiens | Primates | ROS,COX | COX | famplex_relations | COX4I2 | 84701 |
| Homo sapiens | Primates | ROS,COX | COX | famplex_relations | COX6A1 | 1337 |
| Homo sapiens | Primates | ROS,COX | COX | famplex_relations | COX6A2 | 1339 |
| Homo sapiens | Primates | ROS,COX | COX | famplex_relations | COX6B1 | 1340 |
| Homo sapiens | Primates | ROS,COX | COX | famplex_relations | COX6B2 | 125965 |
| Homo sapiens | Primates | ROS,COX | COX | famplex_relations | COX7A1 | 1346 |
| Homo sapiens | Primates | ROS,COX | COX | famplex_relations | COX7A2 | 1347 |
| Homo sapiens | Primates | ROS,COX | COX | famplex_relations | COX7B | 1349 |
| Homo sapiens | Primates | ROS,COX | COX | famplex_relations | COX7B2 | 170712 |
| Homo sapiens | Primates | ROS,COX | COX | famplex_relations | COX8C | 341947 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT1 | 7471 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT2 | 7472 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT2B | 7482 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT3 | 7473 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT3A | 89780 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT4 | 54361 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT6 | 7475 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT7A | 7476 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT7B | 7477 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT8A | 7478 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT8B | 7479 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT9A | 7483 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT9B | 7484 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT10A | 80326 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT10B | 7480 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT11 | 7481 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT16 | 51384 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT5A | 7474 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT5B | 81029 |
| Homo sapiens | Primates | LRP | LRP | ncbigene_synonym | RPSA | 3921 |
| Homo sapiens | Primates | LRP | LRP | ncbigene_synonym | LRP1 | 4035 |
| Homo sapiens | Primates | LRP | LRP | ncbigene_synonym | PTPRA | 5786 |
| Homo sapiens | Primates | LRP | LRP | ncbigene_synonym | MVP | 9961 |
| Homo sapiens | Primates | Frizzled | FZD | famplex_relations | FZD1 | 8321 |
| Homo sapiens | Primates | Frizzled | FZD | famplex_relations | FZD10 | 11211 |
| Homo sapiens | Primates | Frizzled | FZD | famplex_relations | FZD2 | 2535 |
| Homo sapiens | Primates | Frizzled | FZD | famplex_relations | FZD3 | 7976 |
| Homo sapiens | Primates | Frizzled | FZD | famplex_relations | FZD4 | 8322 |
| Homo sapiens | Primates | Frizzled | FZD | famplex_relations | FZD5 | 7855 |
| Homo sapiens | Primates | Frizzled | FZD | famplex_relations | FZD6 | 8323 |
| Homo sapiens | Primates | Frizzled | FZD | famplex_relations | FZD7 | 8324 |
| Homo sapiens | Primates | Frizzled | FZD | famplex_relations | FZD8 | 8325 |
| Homo sapiens | Primates | Frizzled | FZD | famplex_relations | FZD9 | 8326 |
| Homo sapiens | Primates | GSK-3ẞ | GSK3 | famplex_relations | GSK3A | 2931 |
| Homo sapiens | Primates | GSK-3ẞ | GSK3 | famplex_relations | GSK3B | 2932 |
| Homo sapiens | Primates | CKla | CKIA | ncbigene_synonym | CSNK1A1 | 1452 |
| Homo sapiens | Primates | Axin | AXIN | ncbigene_synonym | AXIN1 | 8312 |
| Homo sapiens | Primates | Axin | AXIN | famplex_relations | AXIN2 | 8313 |
| Homo sapiens | Primates | APC | APC | ncbigene_symbol | APC | 324 |
| Homo sapiens | Primates | APC | APC | ncbigene_synonym | PROC | 5624 |
| Homo sapiens | Primates | MRX102 | MRX102 | ncbigene_synonym | DDX3X | 1654 |
| Homo sapiens | Primates | ASPS | ASPS | ncbigene_synonym | CSNK1D | 1453 |
| Homo sapiens | Primates | ASPS | ASPS | ncbigene_synonym | ASPSCR1 | 79058 |
| Homo sapiens | Primates | B-Catenin | CTNNB1 | ncbigene_symbol | CTNNB1 | 1499 |
| Homo sapiens | Primates | TCF/LEF | TCF | ncbigene_synonym | HNF4A | 3172 |
| Word | Match | MeSH | Name | ChEBI |
|---|---|---|---|---|
| Curcumin | curcumin | curcumin | chebi:3962 | |
| Maclurin | Maclurin | chebi:6624 | ||
| Matrine | Matrine | chebi:6700 | ||
| Garcinol | Garcinol | chebi:70328 | ||
| Artemisinin | artemisinin | (3R,5aS,6R,8aS,9R,12S,12aR)-3,6,9-trimethyloctahydro-3,12-epoxypyrano[4,3-j][1,2]benzodioxepin-10(3H)-one | chebi:223316 | |
| Curcumin | curcumin | curcumin | chebi:3962 | |
| Lycorine | Lycorine | 9,10-(methylenedioxy)-3,12-didehydrogalanthan-1alpha,2beta-diol | chebi:6601 | |
| Cinnamaldehyde | cinnamaldehyde | cinnamaldehyde | chebi:142921 | |
| EGCG | EGCG | (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate | chebi:4806 | |
| Patulin | patulin | patulin | chebi:74926 | |
| EGCG | EGCG | (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate | chebi:4806 | |
| Sanguinarine | sanguinarine | sanguinarine | chebi:17183 | |
| Garcinol | Garcinol | chebi:70328 | ||
| Artemisinin | artemisinin | (3R,5aS,6R,8aS,9R,12S,12aR)-3,6,9-trimethyloctahydro-3,12-epoxypyrano[4,3-j][1,2]benzodioxepin-10(3H)-one | chebi:223316 | |
| Artemisinin | artemisinin | (3R,5aS,6R,8aS,9R,12S,12aR)-3,6,9-trimethyloctahydro-3,12-epoxypyrano[4,3-j][1,2]benzodioxepin-10(3H)-one | chebi:223316 | |
| Cinnamaldehyde | cinnamaldehyde | cinnamaldehyde | chebi:142921 | |
| Chelerythrine | chelerythrine | 1,2-dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium | chebi:78373 | |
| Eugenol | eugenol | eugenol | chebi:4917 | |
| Atranorin | atranorin | atranorin | chebi:144119 |
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|