Estrogen metabolism pathway in humans
Estrogen metabolism pathway in humans. The diagram shows the metabolism of estradiol and other natural estrogens such as estrone and estriol. It demonstrates that conjugation (e.g., sulfation and glucuronidation) occurs in the case of estradiol and metabolites of estradiol that have one or more available hydroxyl (–OH) groups. Catechol and quinone formation from estrone is shown and how the derivatives are reacting with DNA to form depurination DNA adducts (adapted from Ref. [16]).
Publication
Estrogens and the risk of breast cancer: A narrative review of literature (2023)
Khayry Al-Shami, et al. Heliyon. 2023 Sep;9(9):e20224. Figure: F3.
Homo sapiens
Organism
Group
Word
Match
Source
NCBI Symbol
NCBI ID
Homo sapiens
Primates
EST
EST
ncbigene_synonym
MAP3K8
1326
Homo sapiens
Primates
EST
EST
ncbigene_synonym
SULT1E1
6783
Homo sapiens
Primates
COMT
COMT
ncbigene_symbol
COMT
1312
Homo sapiens
Primates
STS
STS
ncbigene_symbol
STS
412
Homo sapiens
Primates
UGT1A3
UGT1A3
ncbigene_symbol
UGT1A3
54659
Homo sapiens
Primates
UGT1A3
UGT1A3
ncbigene_synonym
UGT1A6
54578
Homo sapiens
Primates
UGT1A9
UGT1A9
ncbigene_symbol
UGT1A9
54600
Word
Match
MeSH
Name
ChEBI
Estradiol
ESTRADIOL
17beta-estradiol
chebi:16469
Estrone Sulfate
estrone sulfate
17-oxoestra-1,3,5(10)-trien-3-yl hydrogen sulfate
chebi:17474
STS
STS
(5S,6R,7R,9R)-6-methoxy-5-methyl-7-methylamino-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-one
chebi:15738
2-Hydroxyestrone
2-hydroxyestrone
2-hydroxyestrone
chebi:1156
2-Methoxyestrone
2-methoxyestrone
2-methoxyestrone
chebi:1189
Estrone
estrone
estrone
chebi:17263
4-Methoxyestrone
4-methoxyestrone
3-hydroxy-4-methoxyestra-1,3,5(10)-trien-17-one
chebi:136972
DNA
DNA
deoxyribonucleic acids
chebi:16991
17-Epiestriol
17-epiestriol
16alpha,17alpha-estriol
chebi:42156
Estriol
ESTRIOL
16alpha,17beta-estriol
chebi:27974
Disease mentions
Word
Match
MeSH
Name
DOID
