Antagonistic Activity of Oroxylin A against Fusarium graminearum and Its Inhibitory Effect on Zearalenone Production
Common pathway analysis generated by MetaboAnalyst 5.0, based on differential metabolites from both T0 vs. T1 and T0 vs. T2. (A) TCA cycle; (B) pentose phosphate and purine metabolism pathways. For details in figures, refer to the SGD (http://pathway.yeastgenome.org/, assessed on 6 April 2023) and KEGG (http://www.genome.jp/kegg/, assessed on 6 April 2023) databases. Abbreviations: ACO2: aconitase; ADMI: adenosine 5-monophosphate deaminase; AMP: adenosine monophosphate; APTI: adenine phosphoribosyltransferase; CS: citrate synthase; FH: fumarate hydratase; G6PD: glucose-6-phosphate dehydrogenase; IDH: isocitrate dehydrogenase; IMP: inosine monophosphate; KGD: 2-ketoglutarate–dehydrogenase complex; LSC: succinyl-CoA ligase; MDH: malate dehydrogenase; PGD: 6-phosphogluconate dehydrogenase; PGLS: 6-phosphogluconolactonase; PRPP: 5-phospho-alpha-D-ribose 1-diphosphate; PRPS: ribose-phosphate pyrophosphokinase; RPLA: ribose 5-phosphate isomerase A; SDH: succinate dehydrogenase. All data are expressed as the mean ± SEM. Significance: * p < 0.05 and ** p < 0.01. Red color in figure means the differential metabolites.
Publication
Antagonistic Activity of Oroxylin A against Fusarium graminearum and Its Inhibitory Effect on Zearalenone Production. (2023) Luli Zhou, et al. Toxins (Basel). 2023 Sep;15(9):535. Figure: F5.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Drosophila melanogaster | Invertebrates | MDH | MDH | ncbigene_synonym | Mdh1 | 34414 |
| Drosophila melanogaster | Invertebrates | MDH | MDH | ncbigene_synonym | Mdh2 | 42185 |
| Drosophila melanogaster | Invertebrates | MDH | MDH | ncbigene_synonym | Men-b | 43936 |
| Drosophila melanogaster | Invertebrates | MDH | MDH | ncbigene_synonym | Men | 47173 |
| Drosophila melanogaster | Invertebrates | ATP | ATP | ncbigene_synonym | ATPsynbeta | 43829 |
| Drosophila melanogaster | Invertebrates | ATP | ATP | ncbigene_synonym | Atpalpha | 48971 |
| Drosophila melanogaster | Invertebrates | AMP | AMP | ncbigene_synonym | Amph | 36383 |
| Drosophila melanogaster | Invertebrates | FH | FH | ncbigene_symbol | fh | 31845 |
| Drosophila melanogaster | Invertebrates | SDH | SDH | ncbigene_synonym | LKRSDH | 34064 |
| Drosophila melanogaster | Invertebrates | SDH | SDH | ncbigene_synonym | SdhB | 35590 |
| Drosophila melanogaster | Invertebrates | SDH | SDH | ncbigene_synonym | SdhA | 37228 |
| Drosophila melanogaster | Invertebrates | SDH | SDH | ncbigene_synonym | Sodh-2 | 41313 |
| Drosophila melanogaster | Invertebrates | SDH | SDH | ncbigene_synonym | SdhC | 41340 |
| Drosophila melanogaster | Invertebrates | G6PD | G6PD | ncbigene_synonym | Zw | 32974 |
| Drosophila melanogaster | Invertebrates | PGLS | PGLS | ncbigene_symbol | Pgls | 32013 |
| Drosophila melanogaster | Invertebrates | PGD | PGD | ncbigene_symbol | Pgd | 31185 |
| Drosophila melanogaster | Invertebrates | PRPS | PRPS | ncbigene_symbol | Prps | 39132 |
| Drosophila melanogaster | Invertebrates | APT1 | APT1 | ncbigene_symbol | Apt1 | 59176 |
| Drosophila melanogaster | Invertebrates | ST | ST | ncbigene_symbol | st | 39836 |
| Drosophila melanogaster | Invertebrates | LSC | LSC | ncbigene_synonym | l(1)sc | 30983 |
| Drosophila melanogaster | Invertebrates | cycle | CYCLE | ncbigene_synonym | CycE | 34924 |
| Drosophila melanogaster | Invertebrates | cycle | CYCLE | ncbigene_synonym | cyc | 40162 |
| Drosophila melanogaster | Invertebrates | IMP | IMP | ncbigene_symbol | Imp | 32009 |
| Drosophila melanogaster | Invertebrates | IMP | IMP | ncbigene_synonym | CG11110 | 37337 |
| Drosophila melanogaster | Invertebrates | IMP | IMP | ncbigene_synonym | CG17029 | 39740 |
| Drosophila melanogaster | Invertebrates | IMP | IMP | ncbigene_synonym | CG17028 | 39741 |
| Drosophila melanogaster | Invertebrates | IMP | IMP | ncbigene_synonym | CG17027 | 39742 |
| Drosophila melanogaster | Invertebrates | IMP | IMP | ncbigene_synonym | CG9391 | 40346 |
| Drosophila melanogaster | Invertebrates | IMP | IMP | ncbigene_synonym | CG9389 | 40347 |
| Drosophila melanogaster | Invertebrates | TI | TI | ncbigene_symbol | ti | 246793 |
| Drosophila melanogaster | Invertebrates | IDH | IDH | ncbigene_symbol | Idh | 44291 |
| Drosophila melanogaster | Invertebrates | IDH | IDH | ncbigene_synonym | Idh3b | 42586 |
| Homo sapiens | Primates | NADPH | NADPH | ncbigene_synonym | DECR1 | 1666 |
| Homo sapiens | Primates | MDH | MDH | ncbigene_synonym | MDH2 | 4191 |
| Homo sapiens | Primates | ATP | ATP | ncbigene_synonym | ATP8A2 | 51761 |
| Homo sapiens | Primates | AMP | AMP | ncbigene_synonym | APRT | 353 |
| Homo sapiens | Primates | AMP | AMP | ncbigene_synonym | MFAP1 | 4236 |
| Homo sapiens | Primates | FH | FH | ncbigene_symbol | FH | 2271 |
| Homo sapiens | Primates | SDH | SDH | ncbigene_synonym | SARDH | 1757 |
| Homo sapiens | Primates | SDH | SDH | ncbigene_synonym | SDHB | 6390 |
| Homo sapiens | Primates | SDH | SDH | ncbigene_synonym | SORD | 6652 |
| Homo sapiens | Primates | SDH | SDH | ncbigene_synonym | SDS | 10993 |
| Homo sapiens | Primates | G6PD | G6PD | ncbigene_symbol | G6PD | 2539 |
| Homo sapiens | Primates | G6PD | G6PD | ncbigene_synonym | UBL4A | 8266 |
| Homo sapiens | Primates | PGLS | PGLS | ncbigene_symbol | PGLS | 25796 |
| Homo sapiens | Primates | PGD | PGD | ncbigene_symbol | PGD | 5226 |
| Homo sapiens | Primates | PGD | PGD | ncbigene_synonym | PHGDH | 26227 |
| Homo sapiens | Primates | RPIA | RPIA | ncbigene_symbol | RPIA | 22934 |
| Homo sapiens | Primates | PRPS | PRPS | ncbigene_synonym | MSMB | 4477 |
| Homo sapiens | Primates | APT1 | APT1 | ncbigene_synonym | FAS | 355 |
| Homo sapiens | Primates | APT1 | APT1 | ncbigene_synonym | TAP1 | 6890 |
| Homo sapiens | Primates | APT1 | APT1 | ncbigene_synonym | LYPLA1 | 10434 |
| Homo sapiens | Primates | LSC | LSC | ncbigene_synonym | ARHGEF1 | 9138 |
| Homo sapiens | Primates | IMP | IMP | ncbigene_synonym | IMPA1 | 3612 |
| Homo sapiens | Primates | IMP | IMP | ncbigene_synonym | BRAP | 8315 |
| Homo sapiens | Primates | ACO2 | ACO2 | ncbigene_symbol | ACO2 | 50 |
| Homo sapiens | Primates | IDH | IDH | ncbigene_synonym | IDH1 | 3417 |
| Homo sapiens | Primates | IDH | IDH | ncbigene_synonym | IDH2 | 3418 |
| Word | Match | MeSH | Name | ChEBI |
|---|---|---|---|---|
| NADP | NA | mesh:D009249 | ||
| NADPH | NA | mesh:D009249 | ||
| ATP | Adenosine Triphosphate | mesh:D000255 | ATP | chebi:15422 |
| AMP | adenosine 5'-monophosphate | mesh:D000249 | Adenosine Monophosphate | chebi:16027 |
| adenine | Adenine | mesh:D000225 | adenine | chebi:16708 |
| 6-phosphate D-glucono-1,5-lactone | NA | mesh:C106477 | ||
| D-gluconate 6-phosphate | NA | mesh:C008884 | ||
| Purine | Purines | mesh:D011687 | purines | chebi:26401 |
| D-ribulose 5-phosphate | ribulose 5-phosphate | mesh:C031524 | ribulose 5-phosphate | chebi:37455 |
| Glucose | Glucose | mesh:D005947 | D-glucopyranose | chebi:4167 |
| Acetyl-CoA | Acetyl Coenzyme A | mesh:D000105 | acetyl-CoA | chebi:15351 |
| Oxaloacetate | NA | mesh:D010071 | ||
| D-glucopyranose 6-phosphate Pentose phosphate | NA | mesh:D010710 | ||
| Succinate | Succinates | mesh:D013386 | succinate | chebi:26806 |
| Citrate | NA | mesh:C102006 | ||
| diphosphate | NA | mesh:D011756 | ||
| ammonium | Ammonium Compounds | mesh:D064751 | ammonium compound | chebi:35276 |
| TCA | NA | mesh:C000589078 | ||
| Succinyl | NA | mesh:C035687 | ||
| cis-Aconitate | NA | mesh:C043607 | ||
| alpha-ketoglutarate | NA | mesh:C029743 | ||
| Isocitrate | NA | mesh:D007523 |
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|---|---|---|---|
| KGD | NA | mesh:C536582 |