Network pharmacology and experimental verification-based strategy for exploring the mechanisms of luteolin in the treatment of osteosarcoma
The integrated pathways map of luteolin in OS setting. (A) The PI3K-AKT signaling pathway. (B) The IL17 signaling pathway. (C) The TNF signaling pathway. The common targets of luteolin and OS were marked in pink and core targets were marked in red
Publication
Network pharmacology and experimental verification-based strategy for exploring the mechanisms of luteolin in the treatment of osteosarcoma. (2023) Renxuan Huang, et al. Cancer Cell Int. 2023;23:213. Figure: F6.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Drosophila melanogaster | Invertebrates | Mi | MI | ncbigene_symbol | mi | 37723 |
| Drosophila melanogaster | Invertebrates | ww | WW | ncbigene_symbol | ww | 249898 |
| Drosophila melanogaster | Invertebrates | And | AND | ncbigene_synonym | CkIIbeta | 32132 |
| Drosophila melanogaster | Invertebrates | And | AND | ncbigene_synonym | Andorra | 32798 |
| Drosophila melanogaster | Invertebrates | And | AND | ncbigene_synonym | Anp | 43595 |
| Drosophila melanogaster | Invertebrates | And | AND | ncbigene_synonym | Acam | 44913 |
| Drosophila melanogaster | Invertebrates | per | PER | ncbigene_symbol | per | 31251 |
| Drosophila melanogaster | Invertebrates | Pod | POD | ncbigene_symbol | pod | 252447 |
| Drosophila melanogaster | Invertebrates | CAT | CAT | ncbigene_symbol | Cat | 40048 |
| Drosophila melanogaster | Invertebrates | CAT | CAT | ncbigene_synonym | Ca-alpha1T | 31550 |
| Drosophila melanogaster | Invertebrates | CAT | CAT | ncbigene_synonym | ChAT | 42249 |
| Drosophila melanogaster | Invertebrates | CAT | CAT | ncbigene_synonym | sv | 43825 |
| Drosophila melanogaster | Invertebrates | a.r | AR | ncbigene_symbol | ar | 44503 |
| Drosophila melanogaster | Invertebrates | oll | OLI | ncbigene_symbol | Oli | 35066 |
| Drosophila melanogaster | Invertebrates | decad | DECAD | ncbigene_synonym | shg | 37386 |
| Drosophila melanogaster | Invertebrates | cad | CAD | ncbigene_symbol | cad | 35341 |
| Drosophila melanogaster | Invertebrates | cad | CAD | ncbigene_synonym | Drep4 | 34734 |
| Drosophila melanogaster | Invertebrates | cad | CAD | ncbigene_synonym | Ca-alpha1D | 34950 |
| Drosophila melanogaster | Invertebrates | de | DE | ncbigene_symbol | de | 248301 |
| Drosophila melanogaster | Invertebrates | TE | TE | ncbigene_symbol | te | 252809 |
| Drosophila melanogaster | Invertebrates | -TEAM | TEAM | ncbigene_synonym | GlyRS | 39644 |
| Drosophila melanogaster | Invertebrates | PAK | PAK | ncbigene_symbol | Pak | 44039 |
| Drosophila melanogaster | Invertebrates | PAK | PAK | ncbigene_synonym | mbt | 32631 |
| Drosophila melanogaster | Invertebrates | MOR | MOR | ncbigene_symbol | mor | 41942 |
| Drosophila melanogaster | Invertebrates | NES | NES | ncbigene_symbol | nes | 40093 |
| Drosophila melanogaster | Invertebrates | La | LA | ncbigene_symbol | La | 35305 |
| Drosophila melanogaster | Invertebrates | Ap | AP | ncbigene_symbol | ap | 35509 |
| Drosophila melanogaster | Invertebrates | Cha | CHA | ncbigene_symbol | cha | 248106 |
| Drosophila melanogaster | Invertebrates | Fo | FO | ncbigene_symbol | fo | 248762 |
| Drosophila melanogaster | Invertebrates | TEA | TEA | ncbigene_symbol | tea | 36027 |
| Drosophila melanogaster | Invertebrates | PL | PL | ncbigene_symbol | pl | 45344 |
| Drosophila melanogaster | Invertebrates | gr | GR | ncbigene_symbol | gr | 251210 |
| Drosophila melanogaster | Invertebrates | Hy | HY | ncbigene_symbol | hy | 45316 |
| Drosophila melanogaster | Invertebrates | PRA | PRA | ncbigene_symbol | pra | 252453 |
| Drosophila melanogaster | Invertebrates | PRA | PRA | ncbigene_synonym | prg | 34177 |
| Drosophila melanogaster | Invertebrates | IND | IND | ncbigene_symbol | ind | 2768974 |
| Drosophila melanogaster | Invertebrates | IND | IND | ncbigene_synonym | Indented | 251328 |
| Drosophila melanogaster | Invertebrates | ca | CA | ncbigene_symbol | ca | 43518 |
| Drosophila melanogaster | Invertebrates | picky | PICKY | ncbigene_synonym | PGRP-SC1a | 35859 |
| Drosophila melanogaster | Invertebrates | Apk | APK | ncbigene_synonym | Nplp1 | 38003 |
| Drosophila melanogaster | Invertebrates | sig | SIG | ncbigene_synonym | lap | 40863 |
| Drosophila melanogaster | Invertebrates | INT | INT | ncbigene_synonym | up | 32314 |
| Drosophila melanogaster | Invertebrates | agi | AGI | ncbigene_symbol | Agi | 5657748 |
| Drosophila melanogaster | Invertebrates | BAD | BAD | ncbigene_synonym | cass | 35053 |
| Drosophila melanogaster | Invertebrates | STR | STR | ncbigene_symbol | Str | 252736 |
| Drosophila melanogaster | Invertebrates | STR | STR | ncbigene_synonym | tkv | 33753 |
| Drosophila melanogaster | Invertebrates | STR | STR | ncbigene_synonym | stw | 35494 |
| Drosophila melanogaster | Invertebrates | [X2] | X2 | ncbigene_symbol | x2 | 247265 |
| Drosophila melanogaster | Invertebrates | TOR | TOR | ncbigene_symbol | tor | 35717 |
| Drosophila melanogaster | Invertebrates | TOR | TOR | ncbigene_symbol | Tor | 47396 |
| Drosophila melanogaster | Invertebrates | TOR | TOR | ncbigene_synonym | Egfr | 37455 |
| Drosophila melanogaster | Invertebrates | Peg | PEG | ncbigene_symbol | peg | 50050 |
| Drosophila melanogaster | Invertebrates | Peg | PEG | ncbigene_synonym | Sec63 | 38819 |
| Drosophila melanogaster | Invertebrates | SHA | SHA | ncbigene_symbol | sha | 36213 |
| Drosophila melanogaster | Invertebrates | SHA | SHA | ncbigene_synonym | Sh | 32780 |
| Drosophila melanogaster | Invertebrates | SHA | SHA | ncbigene_synonym | Nplp3 | 59235 |
| Drosophila melanogaster | Invertebrates | DOA | DOA | ncbigene_symbol | Doa | 43415 |
| Drosophila melanogaster | Invertebrates | Fog | FOG | ncbigene_symbol | fog | 33148 |
| Drosophila melanogaster | Invertebrates | Fog | FOG | ncbigene_synonym | ush | 33225 |
| Drosophila melanogaster | Invertebrates | Dila | DILA | ncbigene_symbol | dila | 36010 |
| Drosophila melanogaster | Invertebrates | EST | EST | ncbigene_synonym | Est-6 | 39392 |
| Drosophila melanogaster | Invertebrates | CON | CON | ncbigene_symbol | Con | 38590 |
| Drosophila melanogaster | Invertebrates | DIN | DIN | ncbigene_synonym | Axn | 43565 |
| Drosophila melanogaster | Invertebrates | und | UND | ncbigene_symbol | und | 34294 |
| Drosophila melanogaster | Invertebrates | va | VA | ncbigene_symbol | Va | 247258 |
| Drosophila melanogaster | Invertebrates | Cycl | CYCL | ncbigene_synonym | Cypl | 38069 |
| Drosophila melanogaster | Invertebrates | Cycl | CYC1 | ncbigene_synonym | Cyt-c1 | 38612 |
| Drosophila melanogaster | Invertebrates | Com | COM | ncbigene_symbol | COM | 5658320 |
| Drosophila melanogaster | Invertebrates | Com | COM | ncbigene_synonym | comt | 47091 |
| Drosophila melanogaster | Invertebrates | Com | COM | ncbigene_synonym | compressed | 248141 |
| Drosophila melanogaster | Invertebrates | Com | COM | ncbigene_synonym | lncRNA:flam | 26067356 |
| Drosophila melanogaster | Invertebrates | PIPE | PIPE | ncbigene_synonym | pip | 40104 |
| Drosophila melanogaster | Invertebrates | SVE | SVE | ncbigene_symbol | sve | 5658263 |
| Drosophila melanogaster | Invertebrates | Arts | ARTS | ncbigene_symbol | Arts | 59215 |
| Drosophila melanogaster | Invertebrates | Jak | JAK | ncbigene_synonym | hop | 32080 |
| Drosophila melanogaster | Invertebrates | Jak | JAK | ncbigene_synonym | bsk | 44801 |
| Drosophila melanogaster | Invertebrates | L-104 | L104 | ncbigene_synonym | l(1)TK104 | 247550 |
| Drosophila melanogaster | Invertebrates | BE | BE | ncbigene_symbol | be | 32430 |
| Drosophila melanogaster | Invertebrates | HI | HI | ncbigene_symbol | hi | 251220 |
| Drosophila melanogaster | Invertebrates | [PD | PD | ncbigene_symbol | pd | 45913 |
| Drosophila melanogaster | Invertebrates | Coll | COLL | ncbigene_synonym | Col4a1 | 33727 |
| Drosophila melanogaster | Invertebrates | Coll | COIL | ncbigene_symbol | coil | 35785 |
| Drosophila melanogaster | Invertebrates | pig | PIG | ncbigene_symbol | pig | 252326 |
| Drosophila melanogaster | Invertebrates | pig | PIG | ncbigene_synonym | CG15914 | 32542 |
| Drosophila melanogaster | Invertebrates | Col | COL | ncbigene_synonym | Ubc7 | 44054 |
| Drosophila melanogaster | Invertebrates | Col | COL | ncbigene_synonym | kn | 45318 |
| Drosophila melanogaster | Invertebrates | Col | COL | ncbigene_synonym | crl | 27662247 |
| Drosophila melanogaster | Invertebrates | Pr | PR | ncbigene_symbol | pr | 35292 |
| Drosophila melanogaster | Invertebrates | CAL | CAL | ncbigene_symbol | cal | 247962 |
| Drosophila melanogaster | Invertebrates | CAL | CAL | ncbigene_synonym | Cam | 36329 |
| Drosophila melanogaster | Invertebrates | [FIE | FIE | ncbigene_symbol | Fie | 38452 |
| Drosophila melanogaster | Invertebrates | BO | BO | ncbigene_symbol | bo | 247918 |
| Drosophila melanogaster | Invertebrates | Regg | REGG | ncbigene_synonym | REG | 32274 |
| Drosophila melanogaster | Invertebrates | SALM | SALM | ncbigene_symbol | salm | 34569 |
| Drosophila melanogaster | Invertebrates | Ha | HA | ncbigene_symbol | ha | 251217 |
| Drosophila melanogaster | Invertebrates | key | KEY | ncbigene_symbol | key | 37967 |
| Drosophila melanogaster | Invertebrates | pok | POK | ncbigene_synonym | aop | 33392 |
| Drosophila melanogaster | Invertebrates | panas | PANA | ncbigene_symbol | pana | 43986 |
| Drosophila melanogaster | Invertebrates | HP.D | HPD | ncbigene_symbol | Hpd | 40263 |
| Drosophila melanogaster | Invertebrates | mis | MIS | ncbigene_symbol | mis | 249851 |
| Drosophila melanogaster | Invertebrates | mis | MIS | ncbigene_synonym | cno | 40620 |
| Homo sapiens | Primates | per | PER | ncbigene_synonym | PER1 | 5187 |
| Homo sapiens | Primates | CAT | CAT | ncbigene_symbol | CAT | 847 |
| Homo sapiens | Primates | CAT | CAT | ncbigene_synonym | CRAT | 1384 |
| Homo sapiens | Primates | CAT | CAT | ncbigene_synonym | GLYAT | 10249 |
| Homo sapiens | Primates | BCM | BCM | ncbigene_synonym | TNFRSF17 | 608 |
| Homo sapiens | Primates | yes | YES | ncbigene_synonym | YES1 | 7525 |
| Homo sapiens | Primates | a.r | AR | ncbigene_symbol | AR | 367 |
| Homo sapiens | Primates | oll | OI1 | ncbigene_synonym | COL1A1 | 1277 |
| Homo sapiens | Primates | cad | CAD | ncbigene_symbol | CAD | 790 |
| Homo sapiens | Primates | cad | CAD | ncbigene_synonym | DFFB | 1677 |
| Homo sapiens | Primates | cad | CAD | ncbigene_synonym | ACOD1 | 730249 |
| Homo sapiens | Primates | PAK | PAK | famplex_relations | PAK1 | 5058 |
| Homo sapiens | Primates | PAK | PAK | famplex_relations | PAK2 | 5062 |
| Homo sapiens | Primates | PAK | PAK | famplex_relations | PAK3 | 5063 |
| Homo sapiens | Primates | PAK | PAK | famplex_relations | PAK4 | 10298 |
| Homo sapiens | Primates | PAK | PAK | famplex_relations | PAK5 | 57144 |
| Homo sapiens | Primates | PAK | PAK | famplex_relations | PAK6 | 56924 |
| Homo sapiens | Primates | MOR | MOR | ncbigene_synonym | OPRM1 | 4988 |
| Homo sapiens | Primates | ILA | ILA | ncbigene_synonym | TNFRSF9 | 3604 |
| Homo sapiens | Primates | NES | NES | ncbigene_symbol | NES | 10763 |
| Homo sapiens | Primates | Cha | CHA | ncbigene_synonym | TCFL5 | 10732 |
| Homo sapiens | Primates | FIRE | FIRE | ncbigene_synonym | ADGRE4P | 326342 |
| Homo sapiens | Primates | PRAP | PRAP | ncbigene_synonym | SKAP2 | 8935 |
| Homo sapiens | Primates | PRAP | PRAP | ncbigene_synonym | HSD17B7 | 51478 |
| Homo sapiens | Primates | TRAIL | TRAIL | ncbigene_synonym | TNFSF10 | 8743 |
| Homo sapiens | Primates | MATK] | MATK | ncbigene_symbol | MATK | 4145 |
| Homo sapiens | Primates | IL-17 | IL-17 | ncbigene_synonym | IL17A | 3605 |
| Homo sapiens | Primates | Madd | MADD | ncbigene_symbol | MADD | 8567 |
| Homo sapiens | Primates | Madd | MADD | ncbigene_synonym | ETFA | 2108 |
| Homo sapiens | Primates | Madd | MADD | ncbigene_synonym | ETFB | 2109 |
| Homo sapiens | Primates | Madd | MADD | ncbigene_synonym | ETFDH | 2110 |
| Homo sapiens | Primates | PRA | PRA | ncbigene_synonym | S100A6 | 6277 |
| Homo sapiens | Primates | mea1 | MEA1 | ncbigene_symbol | MEA1 | 4201 |
| Homo sapiens | Primates | INT | INT | ncbigene_synonym | INTU | 27152 |
| Homo sapiens | Primates | BAD | BAD | ncbigene_symbol | BAD | 572 |
| Homo sapiens | Primates | STR | STR | ncbigene_synonym | STATH | 6779 |
| Homo sapiens | Primates | TOR | TOR | ncbigene_synonym | RORC | 6097 |
| Homo sapiens | Primates | Fog | FOG | ncbigene_synonym | ZFPM1 | 161882 |
| Homo sapiens | Primates | EST | EST | ncbigene_synonym | MAP3K8 | 1326 |
| Homo sapiens | Primates | EST | EST | ncbigene_synonym | SULT1E1 | 6783 |
| Homo sapiens | Primates | und | UND | ncbigene_synonym | COL14A1 | 7373 |
| Homo sapiens | Primates | L-21 | L21 | ncbigene_synonym | RPL21 | 6144 |
| Homo sapiens | Primates | L-21 | L21 | ncbigene_synonym | IGKV2D-10 | 28890 |
| Homo sapiens | Primates | Cycl | CYCL | ncbigene_synonym | CECR7 | 100130418 |
| Homo sapiens | Primates | Cycl | CYC1 | ncbigene_symbol | CYC1 | 1537 |
| Homo sapiens | Primates | Cycl | CYC1 | ncbigene_synonym | CCNI | 10983 |
| Homo sapiens | Primates | MAA | MAA | ncbigene_synonym | NAA10 | 8260 |
| Homo sapiens | Primates | Arts | ARTS | ncbigene_synonym | SEPTIN4 | 5414 |
| Homo sapiens | Primates | Arts | ARTS | ncbigene_synonym | PRPS1 | 5631 |
| Homo sapiens | Primates | Jak | JAK | famplex_relations | JAK1 | 3716 |
| Homo sapiens | Primates | Jak | JAK | famplex_relations | JAK2 | 3717 |
| Homo sapiens | Primates | Jak | JAK | famplex_relations | JAK3 | 3718 |
| Homo sapiens | Primates | Jak | JAK | famplex_relations | TYK2 | 7297 |
| Homo sapiens | Primates | HT | HT | ncbigene_symbol | HT | 140805 |
| Homo sapiens | Primates | Sell | SELL | ncbigene_symbol | SELL | 6402 |
| Homo sapiens | Primates | Sell | SEI1 | ncbigene_synonym | SERTAD1 | 29950 |
| Homo sapiens | Primates | Sell | SELI | ncbigene_synonym | SELENOI | 85465 |
| Homo sapiens | Primates | Coll | COIL | ncbigene_symbol | COIL | 8161 |
| Homo sapiens | Primates | CAL | CAL | ncbigene_synonym | FBLIM1 | 54751 |
| Homo sapiens | Primates | CAL | CAL | ncbigene_synonym | GOPC | 57120 |
| Homo sapiens | Primates | Een | EEN | ncbigene_synonym | SH3GL1 | 6455 |
| Homo sapiens | Primates | Regg | REGG | ncbigene_synonym | PSME3 | 10197 |
| Homo sapiens | Primates | HP.D | HPD | ncbigene_symbol | HPD | 3242 |
| Homo sapiens | Primates | mis | MIS | ncbigene_synonym | AMH | 268 |
| Word | Match | MeSH | Name | ChEBI |
|---|---|---|---|---|
| TEA | NA | mesh:C488288 | ||
| TADO | NA | mesh:C104680 | ||
| AMPIC | NA | |||
| DHA | NA | mesh:C111716 | ||
| Ta | Tantalum | mesh:D013635 | tantalum atom | chebi:33348 |
| 15L KYA | NA | mesh:C515378 |
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|---|---|---|---|
| MI | NA | mesh:D009203 |