PTM of PGK1, including acetylation, phosphorylation, ubiquitination and O-GlcNAcylation

PTM of PGK1, including acetylation, phosphorylation, ubiquitination and O-GlcNAcylation. A Under insulin stimulation, PI3K/AKT/mTOR pathway regulates the phosphorylation of HDAC3 Ser424, enhances the interaction between HDAC3 and PGK1, leads to the deacetylation of PGK1 K220, and stimulates the activity/function of PGK1. B Glutamine deprivation and hypoxia lead to inhibition of mTOR-mediated phosphorylation of NAA10/ARD1 S228, leading to PGK1 K388 acetylation and Beclin1 S30 phosphorylation, which activates the autophagosome to form the required complex. C Polarized M2 macrophages secrete IL-6 to increase PDPK1-dependent PGK1 phosphorylation at T243 in GBM cells. D The phosphorylation of PGK1 at serine 203 (S203) correlates with the promotion of the Warburg effect, hypoxia, expression of oncogenic genes, and cancer development. E FOXO3A/LINC00926/PGK1 axis regulates breast cancer glycolysis, tumor growth, and lung metastasis both in vitro and in vivo. F SNHG26 binds to PGK1 protein, inhibits its ubiquitination and activates the Akt/mTOR signaling pathway. G NRSN2-AS1, transcribed by SOX2, exerts its tumor promoting activity by binding to PGK1. H PGK1 is dynamically modified reversely by O-GlcNAc at the threonine 255 (T255) site, enhancing PGK1 activity while inducing PGK1 translocation to mitochondria. Ac, acetylation; P, phosphorylation; Ub, ubiquitination; G, O-GlcNAcylation

Publication

Regulation of phosphoglycerate kinase 1 and its critical role in cancer (2023) Kexin Zhang, et al. Cell Commun Signal. 2023;21(5):240. Figure: F3. Homo sapiens

Disease mentions