BMP signalling pathway

BMP signalling pathway. In the canonical BMP signalling pathway, BMP signalling molecules bind and activate the type I receptor and type II receptor. This binding leads to the phosphorylation of Smad1/5/8, with the involvement of Smad6/7. Phosphorylated Smad1/5/8 then forms a complex with Smad4 and translocates to the nucleus, where it regulates gene expression. In the non-canonical BMP signalling pathway, BMP signalling molecules can regulate gene expression by activating various signalling pathways, such as MAPK, PI3K, and PKC.
BMP signalling pathway
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Publication

Signalling pathways in the osteogenic differentiation of periodontal ligament stem cells (2023) Liuyu Ru, et al. Open Life Sci. 2023;18(1):20220706. Figure: F4.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates BMPs BMP famplex_relations BMP1 649
Homo sapiens Primates BMPs BMP famplex_relations BMP2 650
Homo sapiens Primates BMPs BMP famplex_relations BMP3 651
Homo sapiens Primates BMPs BMP famplex_relations BMP4 652
Homo sapiens Primates BMPs BMP famplex_relations BMP5 653
Homo sapiens Primates BMPs BMP famplex_relations BMP6 654
Homo sapiens Primates BMPs BMP famplex_relations BMP7 655
Homo sapiens Primates BMPs BMP famplex_relations BMP8A 353500
Homo sapiens Primates BMPs BMP famplex_relations BMP8B 656
Homo sapiens Primates BMPs BMP famplex_relations BMP10 27302
Homo sapiens Primates BMPs BMP famplex_relations BMP15 9210
Homo sapiens Primates BMPs BMP famplex_relations GDF1 2657
Homo sapiens Primates BMPs BMP famplex_relations GDF2 2658
Homo sapiens Primates BMPs BMP famplex_relations GDF3 9573
Homo sapiens Primates BMPs BMP famplex_relations GDF5 8200
Homo sapiens Primates BMPs BMP famplex_relations GDF6 392255
Homo sapiens Primates BMPs BMP famplex_relations GDF7 151449
Homo sapiens Primates Smad6/7 SMAD6 ncbigene_symbol SMAD6 4091
Homo sapiens Primates Smad6/7 SMAD7 ncbigene_symbol SMAD7 4092
Homo sapiens Primates Smad1 SMAD1 ncbigene_symbol SMAD1 4086
Homo sapiens Primates Smad1 SMAD1 ncbigene_synonym GARS1 2617
Homo sapiens Primates Smad1/5/8 SMAD5 ncbigene_symbol SMAD5 4090
Homo sapiens Primates Smad1/5/8 SMAD8 ncbigene_synonym SMAD9 4093
Homo sapiens Primates Smad4 SMAD4 ncbigene_symbol SMAD4 4089
Homo sapiens Primates MAPK MAPK famplex_relations MAPK1 5594
Homo sapiens Primates MAPK MAPK famplex_relations MAPK3 5595
Homo sapiens Primates MAPK MAPK famplex_relations MAPK11 5600
Homo sapiens Primates MAPK MAPK famplex_relations MAPK12 6300
Homo sapiens Primates MAPK MAPK famplex_relations MAPK13 5603
Homo sapiens Primates MAPK MAPK famplex_relations MAPK14 1432
Homo sapiens Primates MAPK MAPK famplex_relations MAPK8 5599
Homo sapiens Primates MAPK MAPK famplex_relations MAPK9 5601
Homo sapiens Primates MAPK MAPK famplex_relations MAPK10 5602
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates PKC PKC ncbigene_synonym PRRT2 112476
Homo sapiens Primates PKC PKC famplex_relations PRKCA 5578
Homo sapiens Primates PKC PKC famplex_relations PRKCB 5579
Homo sapiens Primates PKC PKC famplex_relations PRKCD 5580
Homo sapiens Primates PKC PKC famplex_relations PRKCE 5581
Homo sapiens Primates PKC PKC famplex_relations PRKCG 5582
Homo sapiens Primates PKC PKC famplex_relations PRKCH 5583
Homo sapiens Primates PKC PKC famplex_relations PRKCI 5584
Homo sapiens Primates PKC PKC famplex_relations PRKCQ 5588
Homo sapiens Primates PKC PKC famplex_relations PRKCZ 5590
Homo sapiens Primates PKC PKC famplex_relations PRKD3 23683

Chemical mentions

Word Match MeSH Name ChEBI
Nucleus nucleus nucleus chebi:33252

Disease mentions

Word Match MeSH Name DOID