NFKB signalling pathway

NF-κB signalling pathway. In the canonical NF-κB signalling pathway, inflammatory factors such as TNF, IL-1, and LPS bind to cell surface receptors, phosphorylating downstream IκB kinase (IKK) and subsequently phosphorylating IκB. Phosphorylated IκB is degraded in the cytoplasm, releasing the p50/p65 complex. This complex translocates to the nucleus and binds to DNA, resulting in the downregulation of osteogenesis-related markers, such as OPN, OCN, Osx, and Runx2. In the non-canonical NF-κB signalling pathway, cytokines such as CD40L, BAFF, and LTβ bind to cell surface receptors, promoting the activation of NIK and IKKα. IKKα phosphorylates p100, leading to partial processing of p100 and the formation of the p52–RelB complex. Subsequently, the p52–RelB complex enters the nucleus and binds to DNA.

Publication

Signalling pathways in the osteogenic differentiation of periodontal ligament stem cells (2023) Liuyu Ru, et al. Open Life Sci. 2023;18(1):20220706. Figure: F2. Homo sapiens

Disease mentions