Details of KEGG pathways of Ras, PI3K-Akt, and MAPK signaling pathway

Details of KEGG pathways of Ras, PI3K-Akt, and MAPK signaling pathway. KEGG = Kyoto encyclopedia of genes and genomes.
Details of KEGG pathways of Ras, PI3K-Akt, and MAPK signaling pathway
Download JPG
View figure at PMC Read paper at PMC
PMC

Publication

Exploring the mechanism of Semen Strychni in treating amyotrophic lateral sclerosis based on network pharmacology (2023) Xiaohui Tang, et al. Medicine (Baltimore). 2023 Sep 08;102(36):e35101. Figure: F9.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates RAS RAS famplex_relations KRAS 3845
Homo sapiens Primates RAS RAS famplex_relations HRAS 3265
Homo sapiens Primates RAS RAS famplex_relations NRAS 4893
Homo sapiens Primates Mal MAL ncbigene_symbol MAL 4118
Homo sapiens Primates Mal MAL ncbigene_synonym MRTFA 57591
Homo sapiens Primates Mal MAL ncbigene_synonym TIRAP 114609
Homo sapiens Primates Mal MAI ncbigene_synonym GSTZ1 2954
Homo sapiens Primates Grb2 GRB2 ncbigene_symbol GRB2 2885
Homo sapiens Primates SOS SOS ncbigene_synonym XYLT2 64132
Homo sapiens Primates SOS SOS famplex_relations SOS1 6654
Homo sapiens Primates SOS SOS famplex_relations SOS2 6655
Homo sapiens Primates (GAP) GAP ncbigene_synonym RASA1 5921
Homo sapiens Primates (GAP) GAP ncbigene_synonym RGS6 9628
Homo sapiens Primates PAK PAK famplex_relations PAK1 5058
Homo sapiens Primates PAK PAK famplex_relations PAK2 5062
Homo sapiens Primates PAK PAK famplex_relations PAK3 5063
Homo sapiens Primates PAK PAK famplex_relations PAK4 10298
Homo sapiens Primates PAK PAK famplex_relations PAK5 57144
Homo sapiens Primates PAK PAK famplex_relations PAK6 56924
Homo sapiens Primates actin ACTIN famplex_relations ACTA1 58
Homo sapiens Primates actin ACTIN famplex_relations ACTA2 59
Homo sapiens Primates actin ACTIN famplex_relations ACTB 60
Homo sapiens Primates actin ACTIN famplex_relations ACTC1 70
Homo sapiens Primates actin ACTIN famplex_relations ACTG1 71
Homo sapiens Primates actin ACTIN famplex_relations ACTG2 72
Homo sapiens Primates NFL NFL ncbigene_synonym NEFL 4747
Homo sapiens Primates Rho RHO ncbigene_symbol RHO 6010
Homo sapiens Primates Rho RHO ncbigene_synonym RHOD 29984
Homo sapiens Primates Rho RHO famplex_relations RHOA 387
Homo sapiens Primates Rho RHO famplex_relations RHOB 388
Homo sapiens Primates Rho RHO famplex_relations RHOC 389
Homo sapiens Primates SHC SHC ncbigene_synonym SHC1 6464
Homo sapiens Primates SHC SHC famplex_relations SHC2 25759
Homo sapiens Primates SHC SHC famplex_relations SHC3 53358
Homo sapiens Primates SHC SHC famplex_relations SHC4 399694
Homo sapiens Primates SHP2 SHP2 ncbigene_synonym PTPN11 5781
Homo sapiens Primates IKK IKK famplex_relations CHUK 1147
Homo sapiens Primates IKK IKK famplex_relations IKBKB 3551
Homo sapiens Primates IKK IKK famplex_relations IKBKG 8517
Homo sapiens Primates IKK IKK famplex_relations IKBKE 9641
Homo sapiens Primates IKK IKK famplex_relations TBK1 29110
Homo sapiens Primates IPs IPS ncbigene_synonym SLC27A4 10999
Homo sapiens Primates IPs IPS ncbigene_synonym ISYNA1 51477
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates BAD BAD ncbigene_symbol BAD 572
Homo sapiens Primates BCL-X BCL-X ncbigene_synonym BCL2L1 598
Homo sapiens Primates PLCY PLCG famplex_relations PLCG1 5335
Homo sapiens Primates PLCY PLCG famplex_relations PLCG2 5336
Homo sapiens Primates AFX AFX ncbigene_synonym FOXO4 4303
Homo sapiens Primates TCR TCR ncbigene_synonym TRBV20OR9-2 6962
Homo sapiens Primates TCR TCR famplex_relations TRA 6955
Homo sapiens Primates TCR TCR famplex_relations TRB 6957
Homo sapiens Primates TCR TCR famplex_relations TRD 6964
Homo sapiens Primates TCR TCR famplex_relations TRG 6965
Homo sapiens Primates MHC/AntigenTCR MHC ncbigene_synonym HLA-C 3107
Homo sapiens Primates LAT LAT ncbigene_symbol LAT 27040
Homo sapiens Primates LAT LAT ncbigene_synonym ORC3 23595
Homo sapiens Primates LAT LAT ncbigene_synonym SPNS1 83985
Homo sapiens Primates PLD PLD ncbigene_synonym GPLD1 2822
Homo sapiens Primates PLD PLD famplex_relations PLD1 5337
Homo sapiens Primates PLD PLD famplex_relations PLD2 5338
Homo sapiens Primates PLD PLD famplex_relations PLD3 23646
Homo sapiens Primates PLD PLD famplex_relations PLD4 122618
Homo sapiens Primates PLD PLD famplex_relations PLD5 200150
Homo sapiens Primates PLD PLD famplex_relations PLD6 201164
Homo sapiens Primates Sec5 SEC5 ncbigene_synonym EXOC2 55770
Homo sapiens Primates PKA PKA famplex_relations PRKAR1A 5573
Homo sapiens Primates PKA PKA famplex_relations PRKAR1B 5575
Homo sapiens Primates PKA PKA famplex_relations PRKAR2A 5576
Homo sapiens Primates PKA PKA famplex_relations PRKAR2B 5577
Homo sapiens Primates PKA PKA famplex_relations PRKACA 5566
Homo sapiens Primates PKA PKA famplex_relations PRKACB 5567
Homo sapiens Primates PKA PKA famplex_relations PRKACG 5568
Homo sapiens Primates GTP GTP ncbigene_synonym MTG1 92170
Homo sapiens Primates RGL RGL ncbigene_synonym RGL1 23179
Homo sapiens Primates RGL RGL famplex_relations RGL2 5863
Homo sapiens Primates RGL RGL famplex_relations RGL3 57139
Homo sapiens Primates Ral RAL ncbigene_synonym RALA 5898
Homo sapiens Primates Ral RAL famplex_relations RALB 5899
Homo sapiens Primates Ral RAI ncbigene_synonym GDF1 2657
Homo sapiens Primates Ral RAI ncbigene_synonym RNH1 6050
Homo sapiens Primates Ral RAI ncbigene_synonym PPP1R13L 10848
Homo sapiens Primates JNK JNK ncbigene_synonym MAPK8 5599
Homo sapiens Primates JNK JNK famplex_relations MAPK9 5601
Homo sapiens Primates JNK JNK famplex_relations MAPK10 5602
Homo sapiens Primates RBP RBP ncbigene_synonym RENBP 5973
Homo sapiens Primates RBP RBP ncbigene_synonym SUGP1 57794
Homo sapiens Primates NMDAR GRIN famplex_relations GRIN1 2902
Homo sapiens Primates NMDAR GRIN famplex_relations GRIN2A 2903
Homo sapiens Primates NMDAR GRIN famplex_relations GRIN2B 2904
Homo sapiens Primates NMDAR GRIN famplex_relations GRIN2C 2905
Homo sapiens Primates NMDAR GRIN famplex_relations GRIN2D 2906
Homo sapiens Primates NMDAR GRIN famplex_relations GRIN3A 116443
Homo sapiens Primates NMDAR GRIN famplex_relations GRIN3B 116444
Homo sapiens Primates CaM CAM ncbigene_synonym CALM1 801
Homo sapiens Primates CaM CAM ncbigene_synonym CALM2 805
Homo sapiens Primates CaM CAM ncbigene_synonym CALM3 808
Homo sapiens Primates CaM CAM ncbigene_synonym KRIT1 889
Homo sapiens Primates CaM CAM ncbigene_synonym CAMKMT 79823
Homo sapiens Primates CDC42 CDC42 ncbigene_symbol CDC42 998
Homo sapiens Primates AR AR ncbigene_symbol AR 367
Homo sapiens Primates H-100 H1OO ncbigene_synonym H1-8 132243
Homo sapiens Primates (GEF) GEF ncbigene_synonym ARHGEF2 9181
Homo sapiens Primates (GEF) GEF ncbigene_synonym SLC2A4RG 56731
Homo sapiens Primates SHOC2 SHOC2 ncbigene_symbol SHOC2 8036
Homo sapiens Primates MAPK MAPK famplex_relations MAPK1 5594
Homo sapiens Primates MAPK MAPK famplex_relations MAPK3 5595
Homo sapiens Primates MAPK MAPK famplex_relations MAPK11 5600
Homo sapiens Primates MAPK MAPK famplex_relations MAPK12 6300
Homo sapiens Primates MAPK MAPK famplex_relations MAPK13 5603
Homo sapiens Primates MAPK MAPK famplex_relations MAPK14 1432
Homo sapiens Primates ELK ELK ncbigene_synonym EPHB1 2047
Homo sapiens Primates ELK ELK ncbigene_synonym KCNH8 131096
Homo sapiens Primates Raf-1 RAF-1 ncbigene_synonym RAF1 5894
Homo sapiens Primates MEK MEK ncbigene_synonym MAP2K7 5609
Homo sapiens Primates MEK MEK famplex_relations MAP2K1 5604
Homo sapiens Primates MEK MEK famplex_relations MAP2K2 5605
Homo sapiens Primates ERK ERK ncbigene_synonym EPHB2 2048
Homo sapiens Primates ETS ETS famplex_relations ETS1 2113
Homo sapiens Primates ETS ETS famplex_relations ETS2 2114
Homo sapiens Primates KSR KSR ncbigene_synonym KSR1 8844
Homo sapiens Primates KSR KSR famplex_relations KSR2 283455
Homo sapiens Primates IMP IMP ncbigene_synonym IMPA1 3612
Homo sapiens Primates IMP IMP ncbigene_synonym BRAP 8315
Homo sapiens Primates Rapl RAPL ncbigene_synonym RASSF5 83593
Homo sapiens Primates Rap RAP ncbigene_synonym LRPAP1 4043
Homo sapiens Primates Repac REPAC ncbigene_synonym RAPGEF5 9771
Homo sapiens Primates PKC PKC ncbigene_synonym PRRT2 112476
Homo sapiens Primates PKC PKC famplex_relations PRKCA 5578
Homo sapiens Primates PKC PKC famplex_relations PRKCB 5579
Homo sapiens Primates PKC PKC famplex_relations PRKCD 5580
Homo sapiens Primates PKC PKC famplex_relations PRKCE 5581
Homo sapiens Primates PKC PKC famplex_relations PRKCG 5582
Homo sapiens Primates PKC PKC famplex_relations PRKCH 5583
Homo sapiens Primates PKC PKC famplex_relations PRKCI 5584
Homo sapiens Primates PKC PKC famplex_relations PRKCQ 5588
Homo sapiens Primates PKC PKC famplex_relations PRKCZ 5590
Homo sapiens Primates PKC PKC famplex_relations PRKD3 23683
Homo sapiens Primates DAO DAO ncbigene_symbol DAO 1610
Homo sapiens Primates DAO DAO ncbigene_synonym AOC1 26
Homo sapiens Primates PLC PLC ncbigene_synonym HSPG2 3339
Homo sapiens Primates PLC PLC famplex_relations PLCE1 51196
Homo sapiens Primates PLC PLC famplex_relations PLCZ1 89869
Homo sapiens Primates PLC PLC famplex_relations PLCB1 23236
Homo sapiens Primates PLC PLC famplex_relations PLCB2 5330
Homo sapiens Primates PLC PLC famplex_relations PLCB3 5331
Homo sapiens Primates PLC PLC famplex_relations PLCB4 5332
Homo sapiens Primates PLC PLC famplex_relations PLCD1 5333
Homo sapiens Primates PLC PLC famplex_relations PLCD3 113026
Homo sapiens Primates PLC PLC famplex_relations PLCD4 84812
Homo sapiens Primates ABL ABL ncbigene_synonym ABL1 25
Homo sapiens Primates ABL ABL ncbigene_synonym MTTP 4547
Homo sapiens Primates ABL ABL ncbigene_synonym DSP-AS1 101928076
Homo sapiens Primates ABL ABL famplex_relations ABL2 27
Homo sapiens Primates Arfб ARF ncbigene_synonym CDKN2A 1029
Homo sapiens Primates Rac1 RAC1 ncbigene_symbol RAC1 5879
Homo sapiens Primates Rac1 RAC1 ncbigene_synonym RNASE1 6035

Chemical mentions

Word Match MeSH Name ChEBI
GDP GDP 5'-O-[(phosphonatooxy)phosphinato]guanosine chebi:58189
Mal mal malate chebi:15595
GTP GTP GTP chebi:37565
CAMP cAMP adenosine 3',5'-(hydrogen phosphate) chebi:17489
PLA PLA chebi:60159
MEK MEK butan-2-one chebi:28398
IMP IMP 5'-O-phosphonatoinosine chebi:58053
IMP IMP 5'-O-phosphonatoinosine chebi:58053
DAO DAO dodecanoic acid chebi:30805
ABL ABL dodecanoic acid chebi:30805

Disease mentions

Word Match MeSH Name DOID