Diagram illustrating the androgen-mediated signal transduction via integrins and the resulting biological activities

Diagram illustrating the androgen-mediated signal transduction via integrins and the resulting biological activities. (A) Integrin-induced cell motility and adhesion are mediated by AR. Activation of iAR by DHT or R1881 affects different subtypes of integrin expression to regulate cell adhesion and motility. RANK/RANKL promotes iAR expression through integrin α2β1 and induces integrin α2β1-involved cell adhesion via FAK/Akt signaling pathway. In AR-expressing cells, FAK signaling modulates integrin α5β1-induced cell adhesion and integrin αv-induced cell motility. (B) Integrin-induced cell growth and survival are mediated by AR. Activation of iAR by R1881 induces the expression of integrin α6β1, which in turn regulates cell survival through HIF-1α-promoted BNIP3 expression. Furthermore, iAR activity is up-regulated by integrin αvβ6, leading to increased survivin expression and enhanced cell growth. The activation of IGF-IR suppresses the degradation of integrin α5β1 through endocytosis, allowing this remaining integrin α5β1 to induce cell growth. The brown arrows indicate RANK/integrin α2β1/ transcription factor (TF)/iAR and RANK/integrin α2β1/FAK/Akt pathways; The dark blue arrows indicate integrin α5β1/FAK/Akt pathway; The purple arrows indicate integrin αv/FAK/mTOR pathway; The light blue arrows indicate IGF-1R/ integrin α5β1 pathway; The red arrows indicate R1881/iAR/integrin α6β1 pathway; The green arrows indicate integrin αvβ6/JNK/iAR (activity)/survivin pathway; The orange arrows indicate integrin α6β1/HIF-1α/BNIP3 pathway

Publication

Integrins and Actions of Androgen in Breast Cancer (2023) Chung-Che Tsai, et al. Cells. 2023 Sep;12(17). Figure: F3. Homo sapiens

Disease mentions