Mechanism diagram

Mechanism diagram. MSCs in leukemia niche exhibite alterations in multilineage differentiation, cell cycle, cell senescence and gene expression profiles, and exert pro-proliferative effects through overexpression of IFI6. Mechanistically, IFI6 might promote the proliferation of B-ALL cells by stimulating the SDF-1/CXCR4 axis to activate the ERK signaling pathway, targeting IFI6 or related signaling pathways might be an important measure to reduce leukemia cell proliferation. *The indicator is statistically different in at least one of the comparisons
Mechanism diagram
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Publication

BM-MSCs display altered gene expression profiles in B-cell acute lymphoblastic leukemia niches and exert pro-proliferative effects via overexpression of IFI6 (2023) Chengyun Pan, et al. J Transl Med. 2023;21(2):593. Figure: F8.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates MSCs MSC ncbigene_symbol MSC 9242
Homo sapiens Primates MSCs MSC ncbigene_synonym SLC25A37 51312
Homo sapiens Primates POU5F1* POU5F1 ncbigene_symbol POU5F1 5460
Homo sapiens Primates POU5F1* POU5F1 ncbigene_synonym POU5F1P3 642559
Homo sapiens Primates POU5F1* POU5F1 ncbigene_synonym POU5F1P4 645682
Homo sapiens Primates SOX2 SOX2 ncbigene_symbol SOX2 6657
Homo sapiens Primates NANOG NANOG ncbigene_symbol NANOG 79923
Homo sapiens Primates HOXB4 HOXB4 ncbigene_symbol HOXB4 3214
Homo sapiens Primates SDF-1 SDF1 ncbigene_synonym CXCL12 6387
Homo sapiens Primates P53* P53 ncbigene_synonym TP53 7157
Homo sapiens Primates P53* P53 famplex_relations TP63 8626
Homo sapiens Primates P53* P53 famplex_relations TP73 7161
Homo sapiens Primates P21* P21 ncbigene_synonym CDKN1A 1026
Homo sapiens Primates P21* P21 ncbigene_synonym TCEAL1 9338
Homo sapiens Primates P21* P21 ncbigene_synonym NSG1 27065
Homo sapiens Primates P21* P21 ncbigene_synonym H3P16 644914
Homo sapiens Primates P16 P16 ncbigene_synonym CDKN2A 1029
Homo sapiens Primates P16 P16 ncbigene_synonym H3P10 115482713
Homo sapiens Primates CXCR4 CXCR4 ncbigene_symbol CXCR4 7852
Homo sapiens Primates ERK1 ERK1 ncbigene_synonym MAPK3 5595
Homo sapiens Primates ERK1/2 ERK2 ncbigene_synonym MAPK1 5594

Chemical mentions

Word Match MeSH Name ChEBI
AMD3100 AMD3100 1,1'-(benzene-1,4-diyldimethanediyl)bis(1,4,8,11-tetraazacyclotetradecane) chebi:125354
PD98059 PD98059 2-(2-amino-3-methoxyphenyl)-4H-chromen-4-one chebi:77954

Disease mentions

Word Match MeSH Name DOID
leukemia leukemia leukemia DOID:1240