Single-cell transcriptomics reveals multiple chemoresistant properties in leukemic stem and progenitor cells in pediatric AML
Working model. In AML, HSPC-like leukemic cell populations exhibited one of two known chemoresistance-related expression signatures (LSC and OXPHOS) derived from mouse models (left panel). Among them, HSC-like leukemic cells characterized by the surface marker CD69 possessed chemoresistant capacity possibly via the CD69-mTOR axis. Suppression of the mTOR signaling pathway, in the CD69+ HSC-like cell subpopulation and CD69-overexpressing cell lines, might lead to cell quiescence via suppression of cell cycle regulators CCND1 and CDK6 (as shown in Figs. a and b, and Fig. S5a) and cell adhesion to stromal cells such as MSCs through the CXCR4-CXCL12 interaction (as shown in Fig. d, f). Patients with the CD69+ HSC-like subpopulation were associated with M0/M1 subtypes and specific genomic alterations and had worse clinical outcomes (right panel)
Publication
Single-cell transcriptomics reveals multiple chemoresistant properties in leukemic stem and progenitor cells in pediatric AML. (2023) Yongping Zhang, et al. Genome Biol. 2023;24:199. Figure: F8.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Homo sapiens | Primates | LSC | LSC | ncbigene_synonym | ARHGEF1 | 9138 |
| Homo sapiens | Primates | CD69* | CD69 | ncbigene_symbol | CD69 | 969 |
| Homo sapiens | Primates | CD34 | CD34 | ncbigene_symbol | CD34 | 947 |
| Homo sapiens | Primates | CD34 | CD34 | ncbigene_synonym | FCGR1BP | 2210 |
| Homo sapiens | Primates | MTOR | MTOR | ncbigene_symbol | MTOR | 2475 |
| Homo sapiens | Primates | CCND1) | CCND1 | ncbigene_symbol | CCND1 | 595 |
| Homo sapiens | Primates | (CDK6, | CDK6 | ncbigene_symbol | CDK6 | 1021 |
| Homo sapiens | Primates | (CXCR4) | CXCR4 | ncbigene_symbol | CXCR4 | 7852 |
| Homo sapiens | Primates | CXCL12 | CXCL12 | ncbigene_symbol | CXCL12 | 6387 |
| Homo sapiens | Primates | MSC) | MSC | ncbigene_symbol | MSC | 9242 |
| Homo sapiens | Primates | MSC) | MSC | ncbigene_synonym | SLC25A37 | 51312 |
| Homo sapiens | Primates | cohesin | COHESIN | famplex_relations | RAD21 | 5885 |
| Homo sapiens | Primates | cohesin | COHESIN | famplex_relations | SMC3 | 9126 |
| Homo sapiens | Primates | TP53, | TP53 | ncbigene_symbol | TP53 | 7157 |
| Homo sapiens | Primates | sets | SET | ncbigene_symbol | SET | 6418 |
| Word | Match | MeSH | Name | ChEBI |
|---|---|---|---|---|
| GMP | NA | mesh:C068152 |
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|---|---|---|---|
| AML | NA | mesh:D015470 |