STING signaling pathway inhibition by STINGB in various ways and at various steps

STING signaling pathway inhibition by STING-β in various ways and at various steps. (A) The splicing of the STING pre-mRNA produces a mature mRNA molecule that can be translated to generate a STING-β protein isoform lacking a membrane binding domain but has a CTD domain that enables its binding to STING ligands. (B) The interaction of STING-β with the cGAMP blocks cGAMP binding to the membrane-bound STING isoform resulting in the inhibition of all the upcoming interactions. (C) The cGAMP bound STING-β and STING heterodimer complex cannot relocate to the Golgi body due to STING-β’s lack of transmembrane domain. (D) STING-β may bind to the free TBK1 and block its interaction with the cGAMP-STING homodimer complex preventing the NF-kB and IRF3 activation and subsequent cytokine production. Image created with BioRender.com, accessed on 17 May 2023

Publication

Immunomodulatory Gene-Splicing Dysregulation in Tumorigenesis: Unmasking the Complexity (2023) Lorraine Tshegofatso Maebele, et al. Molecules. 2023 Aug;28(16). Figure: F6. Homo sapiens

Disease mentions