Fusobacterium affects chemotherapy drugs
Fusobacterium affects chemotherapy drugs. Through Toll-like receptor 4 (TLR4) and myeloid differentiation factor 88 (Myd88) of the TLR signaling pathway, Fusobacterium nucleatum induces the selective loss of two autophagy-related microRNAs (microRNA-18a [miR-18a] and microRNA-4802 [miR-4802MYD88]), which activate autophagy, thereby reducing the antitumor activity of oxaliplatin and 5-fluorouracil. Fn.: Fusobacterium nucleatum; LPS: lipopolysaccharide; miR-18a*: ‘*’ represents the by-product with a relatively low content; L-OHP: Oxaliplatin. By Figdraw, www.figdraw.com (accessed on 5 March 2023)
Publication
Intestinal Flora in Chemotherapy Resistance of Biliary Pancreatic Cancer (2023) Liuhui Bai, et al. Biology (Basel). 2023 Aug;12(8). Figure: F2.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Homo sapiens | Primates | LPS | LPS | ncbigene_synonym | IRF6 | 3664 |
| Homo sapiens | Primates | TLR4 | TLR4 | ncbigene_symbol | TLR4 | 7099 |
| Homo sapiens | Primates | MyD88 | MYD88 | ncbigene_symbol | MYD88 | 4615 |
| Homo sapiens | Primates | miR-18a*/miR-4802 | MIR-18A | ncbigene_synonym | MIR18A | 406953 |
| Homo sapiens | Primates | miR-4802 | MIR4802 | ncbigene_symbol | MIR4802 | 100616274 |
| Word | Match | MeSH | Name | ChEBI |
|---|---|---|---|---|
| LPS | LPS | chebi:89981 |
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|