Function and mechanism of PARP inhibitor in thyroid cancers

Schematic model of the function and mechanism of PARP inhibitor in thyroid cancers. Niraparib not only promotes the DNA damage accumulation in TCs but also inhibits the transcription of DIMT1 through promoting Pol II pausing in a PAR-dependent manner, which leads to a global translation shut-down in TCs. Meanwhile, niraparib activates the NF-κB signaling pathway by inhibiting the PARylation of p65, which decreases its ubiquitination and degradation level through E3 ubiquitin ligase RNF146. Moreover, inhibition of the NF-κB pathway augmented the antitumor effect of niraparib in TCs

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PARP inhibitor shuts down the global translation of thyroid cancer through promoting Pol II binding to DIMT1 pause (2023) Xiukun Hou, et al. Int J Biol Sci. 2023;19(12). Figure: F8. Homo sapiens

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