Comprehensive Review: Unveiling the Pro-Oncogenic Roles of IL-1ß and PD-1/PD-L1 in NSCLC Development and Targeting Their Pathways for Clinical Management

Mechanism of the IL-1β pathway and its downstream effects. Legend: GSDMD—gasdermin D; IRAK—IL-1 receptor-associated kinase; MYD88—myeloid differentiation primary response 88; TRAF6—tumor necrosis factor receptor associated factor 6; MAPK—mitogen-activated protein kinase; IkB—inhibitor of nuclear factor kappa B; NF-kB (nuclear factor kappa B); AP-1—activator protein 1.
Comprehensive Review: Unveiling the Pro-Oncogenic Roles of IL-1ß and PD-1/PD-L1 in NSCLC Development and Targeting Their Pathways for Clinical Management
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Comprehensive Review: Unveiling the Pro-Oncogenic Roles of IL-1ß and PD-1/PD-L1 in NSCLC Development and Targeting Their Pathways for Clinical Management. (2023) Dani Ran Castillo, et al. Int J Mol Sci. 2023 Jul;24(14):11547. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates IL-1 IL-1 ncbigene_synonym IL1B 3553
Homo sapiens Primates IRAK3 IRAK3 ncbigene_symbol IRAK3 11213
Homo sapiens Primates IL-18 IL-18 ncbigene_synonym IL18 3606
Homo sapiens Primates IRAK4 IRAK4 ncbigene_symbol IRAK4 51135
Homo sapiens Primates IRAK2 IRAK2 ncbigene_symbol IRAK2 3656
Homo sapiens Primates MAPK MAPK famplex_relations MAPK1 5594
Homo sapiens Primates MAPK MAPK famplex_relations MAPK3 5595
Homo sapiens Primates MAPK MAPK famplex_relations MAPK11 5600
Homo sapiens Primates MAPK MAPK famplex_relations MAPK12 6300
Homo sapiens Primates MAPK MAPK famplex_relations MAPK13 5603
Homo sapiens Primates MAPK MAPK famplex_relations MAPK14 1432
Homo sapiens Primates MAPK MAPK famplex_relations MAPK8 5599
Homo sapiens Primates MAPK MAPK famplex_relations MAPK9 5601
Homo sapiens Primates MAPK MAPK famplex_relations MAPK10 5602
Homo sapiens Primates c-jun C-JUN ncbigene_synonym JUN 3725
Homo sapiens Primates c-fos C-FOS ncbigene_synonym FOS 2353
Homo sapiens Primates AP-1 AP-1 ncbigene_synonym FOSB 2354
Homo sapiens Primates AP-1 AP-1 ncbigene_synonym JUNB 3726
Homo sapiens Primates AP-1 AP-1 ncbigene_synonym JUND 3727
Homo sapiens Primates IRAK1 IRAK1 ncbigene_symbol IRAK1 3654
Homo sapiens Primates TRAF6 TRAF6 ncbigene_symbol TRAF6 7189
Homo sapiens Primates MYD88 MYD88 ncbigene_symbol MYD88 4615
Homo sapiens Primates GSDMD GSDMD ncbigene_symbol GSDMD 79792
Homo sapiens Primates NF-kB NF-KB ncbigene_synonym NFKB1 4790

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID