Canonical Wnt signal transduction pathway
Schematic representation of the canonical Wnt signal transduction pathway. (Left) The destruction complex of Axin, APC, GSK-3β, CK1α, and β-catenin is formed when the Wnt ligands are not present in the cytosol, and β-catenin is phosphorylated by CK1α and GSK-3β. (Right) In the presence of Wnt ligands, the signalling pathway is stimulated by recruiting Dvl and Axin proteins to the cell membrane and binding to the receptors (Fzd) and co-receptors (LRP5/6) consecutively. This process allows for stabilisation of β-catenin in the cytosol and translocation into the nucleus for signal transduction
Publication
Characterising the Effect of Wnt/β-Catenin Signalling on Melanocyte Development and Patterning: Insights from Zebrafish (Danio rerio) (2023) Praneeth Silva, et al. Int J Mol Sci. 2023 Jul;24(13). Figure: F2.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT1 | 7471 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT2 | 7472 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT2B | 7482 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT3 | 7473 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT3A | 89780 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT4 | 54361 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT6 | 7475 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT7A | 7476 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT7B | 7477 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT8A | 7478 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT8B | 7479 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT9A | 7483 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT9B | 7484 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT10A | 80326 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT10B | 7480 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT11 | 7481 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT16 | 51384 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT5A | 7474 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT5B | 81029 |
| Homo sapiens | Primates | LRP5 | LRP5 | ncbigene_symbol | LRP5 | 4041 |
| Homo sapiens | Primates | LRP5/6 | LRP6 | ncbigene_symbol | LRP6 | 4040 |
| Homo sapiens | Primates | Fzd | FZD | famplex_relations | FZD1 | 8321 |
| Homo sapiens | Primates | Fzd | FZD | famplex_relations | FZD10 | 11211 |
| Homo sapiens | Primates | Fzd | FZD | famplex_relations | FZD2 | 2535 |
| Homo sapiens | Primates | Fzd | FZD | famplex_relations | FZD3 | 7976 |
| Homo sapiens | Primates | Fzd | FZD | famplex_relations | FZD4 | 8322 |
| Homo sapiens | Primates | Fzd | FZD | famplex_relations | FZD5 | 7855 |
| Homo sapiens | Primates | Fzd | FZD | famplex_relations | FZD6 | 8323 |
| Homo sapiens | Primates | Fzd | FZD | famplex_relations | FZD7 | 8324 |
| Homo sapiens | Primates | Fzd | FZD | famplex_relations | FZD8 | 8325 |
| Homo sapiens | Primates | Fzd | FZD | famplex_relations | FZD9 | 8326 |
| Homo sapiens | Primates | GSK-3B | GSK3B | ncbigene_symbol | GSK3B | 2932 |
| Homo sapiens | Primates | Dvl | DVL | ncbigene_synonym | DVL1 | 1855 |
| Homo sapiens | Primates | Dvl | DVL | ncbigene_synonym | DVL1P1 | 8215 |
| Homo sapiens | Primates | Dvl | DVL | famplex_relations | DVL2 | 1856 |
| Homo sapiens | Primates | Dvl | DVL | famplex_relations | DVL3 | 1857 |
| Homo sapiens | Primates | Axin | AXIN | ncbigene_synonym | AXIN1 | 8312 |
| Homo sapiens | Primates | Axin | AXIN | famplex_relations | AXIN2 | 8313 |
| Homo sapiens | Primates | CK1a | CK1A | ncbigene_synonym | CSNK1A1 | 1452 |
| Homo sapiens | Primates | APC | APC | ncbigene_symbol | APC | 324 |
| Homo sapiens | Primates | APC | APC | ncbigene_synonym | PROC | 5624 |
| Homo sapiens | Primates | TCF/LEF | TCF | ncbigene_synonym | HNF4A | 3172 |
| Word | Match | MeSH | Name | ChEBI |
|---|---|---|---|---|
| Nucleus | nucleus | nucleus | chebi:33252 |
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|