Major pathways and interactions regulated by GSK3B: (A) Wnt/B-catenin pathway and (B)PI3K/Akt/mTor pathway

The major pathways and interactions regulated by GSK3B: (A) Wnt/B-catenin pathway and (B)PI3K/Akt/mTor pathway. In the Wnt/B-catenin pathway, the binding of Wnt to LRP causes the GSK3B complex with other proteins to be inhibited. This same complex phosphorylates the LRP/Wnt/ligand complex. The inhibited GSK3B complex stabilizes this pathway and causes the accumulation of B-catenin outside of the plasma membrane. B-catenin then translocates into the nucleus and forms a complex with the TCF/LEF transcription factors, which reduces transcription and DNA binding. In the PI3K/Akt/mTor pathway, the binding of the growth factor to the receptor tyrosine kinase stimulates PI3K and PIP3 activity, which then stimulates Akt activity. This activation leads to the phosphorylation of GSK3B, which inactivates the protein. Once GSK3B is inhibited, the assembly of B-catenin is regulated for the Wnt signaling that is important to maintain synaptic signaling

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Investigation of Potential Drug Targets for Cholesterol Regulation to Treat Alzheimer’s Disease (2023) Marina Passero, et al. Int J Environ Res Public Health. 2023 Jul;20(13). Figure: F3. Homo sapiens

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