Adiponectin and metabolic cardiovascular diseases: Therapeutic opportunities and challenges

The mechanism by which adiponectin promotes angiogenesis. Adiponectin stimulates angiogenesis to repair damaged blood vessels: globular adiponectin reverses high glucose-impaired functions of endothelial progenitor cells (EPC) through the restoration of eNOS activity and p38 MAPK-related mechanisms; full-length adiponectin increases endothelial cell proliferation and the expression of MMP-2, MMP-9 and vascular endothelial growth factor; adiponectin stimulates angiogenesis via the AMPK-eNOS pathway and Akt signaling and increases endothelial cell proliferation and migration in vitro via the AdipoR1 and AMPK-Akt pathways.
Adiponectin and metabolic cardiovascular diseases: Therapeutic opportunities and challenges
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Publication

Adiponectin and metabolic cardiovascular diseases: Therapeutic opportunities and challenges. (2023) Xiaotian Lei, et al. Genes Dis. 2023 Jul;10(4):1525-1536. Figure: F2.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates (P38 P38 ncbigene_synonym CRK 1398
Homo sapiens Primates (P38 P38 ncbigene_synonym MAPK14 1432
Homo sapiens Primates (P38 P38 ncbigene_synonym MAPK1 5594
Homo sapiens Primates (P38 P38 ncbigene_synonym AIMP2 7965
Homo sapiens Primates (P38 P38 ncbigene_synonym GRAP2 9402
Homo sapiens Primates (P38 P38 ncbigene_synonym AHSA1 10598
Homo sapiens Primates (P38 P38 ncbigene_synonym POLDIP2 26073
Homo sapiens Primates (P38 P38 famplex_relations MAPK11 5600
Homo sapiens Primates (P38 P38 famplex_relations MAPK12 6300
Homo sapiens Primates (P38 P38 famplex_relations MAPK13 5603
Homo sapiens Primates MAPK) MAPK famplex_relations MAPK3 5595
Homo sapiens Primates MAPK) MAPK famplex_relations MAPK8 5599
Homo sapiens Primates MAPK) MAPK famplex_relations MAPK9 5601
Homo sapiens Primates MAPK) MAPK famplex_relations MAPK10 5602
Homo sapiens Primates eNOS ENOS ncbigene_synonym NOS3 4846
Homo sapiens Primates eNOS ENOS ncbigene_synonym ENO4 387712
Homo sapiens Primates AdipoR1 ADIPOR1 ncbigene_symbol ADIPOR1 51094
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAA1 5562
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAA2 5563
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAB1 5564
Homo sapiens Primates AMPK AMPK famplex_relations PRKAB2 5565
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG1 5571
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG2 51422
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG3 53632
Homo sapiens Primates PI3K/AKT AKT ncbigene_synonym AKT1 207
Homo sapiens Primates PI3K/AKT AKT famplex_relations AKT2 208
Homo sapiens Primates PI3K/AKT AKT famplex_relations AKT3 10000
Homo sapiens Primates PI3K/AKT PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3K/AKT PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3K/AKT PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3K/AKT PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3K/AKT PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3K/AKT PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3K/AKT PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3K/AKT PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3K/AKT PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3K/AKT PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates AdipoR2 ADIPOR2 ncbigene_symbol ADIPOR2 79602
Homo sapiens Primates WIMP-2,MMP- MMP famplex_relations MMP1 4312
Homo sapiens Primates WIMP-2,MMP- MMP famplex_relations MMP2 4313
Homo sapiens Primates WIMP-2,MMP- MMP famplex_relations MMP3 4314
Homo sapiens Primates WIMP-2,MMP- MMP famplex_relations MMP7 4316
Homo sapiens Primates WIMP-2,MMP- MMP famplex_relations MMP8 4317
Homo sapiens Primates WIMP-2,MMP- MMP famplex_relations MMP9 4318
Homo sapiens Primates WIMP-2,MMP- MMP famplex_relations MMP10 4319
Homo sapiens Primates WIMP-2,MMP- MMP famplex_relations MMP11 4320
Homo sapiens Primates WIMP-2,MMP- MMP famplex_relations MMP12 4321
Homo sapiens Primates WIMP-2,MMP- MMP famplex_relations MMP13 4322
Homo sapiens Primates WIMP-2,MMP- MMP famplex_relations MMP14 4323
Homo sapiens Primates WIMP-2,MMP- MMP famplex_relations MMP15 4324
Homo sapiens Primates WIMP-2,MMP- MMP famplex_relations MMP16 4325
Homo sapiens Primates WIMP-2,MMP- MMP famplex_relations MMP17 4326
Homo sapiens Primates WIMP-2,MMP- MMP famplex_relations MMP19 4327
Homo sapiens Primates WIMP-2,MMP- MMP famplex_relations MMP20 9313
Homo sapiens Primates WIMP-2,MMP- MMP famplex_relations MMP21 118856
Homo sapiens Primates WIMP-2,MMP- MMP famplex_relations MMP23B 8510
Homo sapiens Primates WIMP-2,MMP- MMP famplex_relations MMP24 10893
Homo sapiens Primates WIMP-2,MMP- MMP famplex_relations MMP25 64386
Homo sapiens Primates WIMP-2,MMP- MMP famplex_relations MMP26 56547
Homo sapiens Primates WIMP-2,MMP- MMP famplex_relations MMP27 64066
Homo sapiens Primates WIMP-2,MMP- MMP famplex_relations MMP28 79148
Homo sapiens Primates VEGF VEGF ncbigene_synonym VEGFA 7422
Homo sapiens Primates VEGF VEGF famplex_relations VEGFB 7423
Homo sapiens Primates VEGF VEGF famplex_relations VEGFC 7424
Homo sapiens Primates VEGF VEGF famplex_relations VEGFD 2277
Homo sapiens Primates VEGF VEGF famplex_relations PGF 5228
Homo sapiens Primates HMW HMW ncbigene_synonym CFAP97 57587
Homo sapiens Primates T-cadherin CDH13 ncbigene_symbol CDH13 1012

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID