DEAD-box RNA helicases with special reference to p68: Unwinding their biology, versatility, and therapeutic opportunity in cancer

p68: a crucial switch for the major signaling pathways and crosstalks. In the signaling crosstalk between the four major pathways namely EGFR pathway, Wnt pathway, NF-κB pathway and Notch pathway, p68 plays a crucial role as a connecting link between these pathways and helping in the switch from one pathway to another. Due to this, the downstream target genes get activated and thereafter mediate the progression of cancer through their physiological functions. This highlights the effective role played by p68 in being the unique common player that helps in regulating the factors like p38 MAP kinase, Stat3, Akt, β-catenin and MAML1 involved in the major signaling axis.

Publication

DEAD-box RNA helicases with special reference to p68: Unwinding their biology, versatility, and therapeutic opportunity in cancer. (2023) Shaheda Tabassum, et al. Genes Dis. 2023 Jul;10(4):1220-1241. Figure: F4. All organisms Drosophila melanogaster Homo sapiens

Disease mentions