Cysteine dioxygenase type 1 (CDO1): Its functional role in physiological and pathophysiological processes
CDO1 catalyzes the metabolic pathway of cysteine. CDO1 can transfer two oxygen atoms of oxygen to the sulfur of cysteine, forming CSA. CSA is converted to hypotaurine by CSAD; hypotaurine is eventually oxidated to taurine by HDH. In addition, CSA is transaminated by GOT1 to produce β-sulfinylpyruvate, which spontaneously dissociates to give rise to pyruvate and sulfite. Sulfite is further oxidized to by SUOX. On the other hand, CDO1 reduces the synthesis of GSH and H2S by promoting cysteine metabolism. CSA, cysteine sulfinic acid CSAD, cysteine sulfinate decarboxylase; HDH, hypotaurine dehydrogenase; GOT1, cytosolic aspartate aminotransferase; , sulfate; SUOX, sulfite oxidase.
Publication
Cysteine dioxygenase type 1 (CDO1): Its functional role in physiological and pathophysiological processes. (2023) Min Chen, et al. Genes Dis. 2023 May;10(3):877-890. Figure: F3.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Homo sapiens | Primates | GOT1 | GOT1 | ncbigene_symbol | GOT1 | 2805 |
| Homo sapiens | Primates | GOT1 | GOT1 | ncbigene_synonym | GOLT1B | 51026 |
| Homo sapiens | Primates | GOT1 | GOT1 | ncbigene_synonym | GOLT1A | 127845 |
| Homo sapiens | Primates | CSA | CSA | ncbigene_synonym | ERCC8 | 1161 |
| Homo sapiens | Primates | CSA | CSA | ncbigene_synonym | CSH1 | 1442 |
| Homo sapiens | Primates | CSA | CSA | ncbigene_synonym | HSPA9 | 3313 |
| Homo sapiens | Primates | SUOX | SUOX | ncbigene_symbol | SUOX | 6821 |
| Homo sapiens | Primates | CDO1 | CDO1 | ncbigene_symbol | CDO1 | 1036 |
| Homo sapiens | Primates | CSAD | CSAD | ncbigene_symbol | CSAD | 51380 |
| Danio rerio | Vertebrates | GOT1 | GOT1 | ncbigene_symbol | got1 | 406330 |
| Danio rerio | Vertebrates | GOT1 | GOT1 | ncbigene_synonym | got1l1 | 791730 |
| Danio rerio | Vertebrates | CSA | CSA | ncbigene_synonym | ercc8 | 449811 |
| Danio rerio | Vertebrates | SUOX | SUOX | ncbigene_symbol | suox | 566675 |
| Danio rerio | Vertebrates | CDO1 | CDO1 | ncbigene_symbol | cdo1 | 393714 |
| Danio rerio | Vertebrates | CSAD | CSAD | ncbigene_symbol | csad | 492476 |
| Word | Match | MeSH | Name | ChEBI |
|---|---|---|---|---|
| Cys | NA | mesh:C046557 | ||
| GSH | Glutathione | mesh:D005978 | glutathione | chebi:16856 |
| Pyruvate | NA | mesh:D011773 | ||
| Cysteine | Cysteine | mesh:D003545 | cysteine | chebi:15356 |
| B-sulfinylpyruvate | Boron | mesh:D001895 | boron atom | chebi:27560 |
| CSA | Cyclosporine | mesh:D016572 | cyclosporin A | chebi:4031 |
| Hypotaurine | NA | mesh:C003949 | ||
| Taurine | Taurine | mesh:D013654 | taurine | chebi:15891 |
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|