Graphical summary of the signaling pathway that mediates fenofibrate (FF)-induced cytoprotection against cisplatin toxicity
Graphical summary of the signaling pathway that mediates fenofibrate (FF)-induced cytoprotection against cisplatin toxicity. ↑, increase; ↓, decrease; PPAR-α, peroxisome proliferator-activated receptor-α; PPRE, peroxisome proliferator response element; AhR, aryl hydrocarbon receptor; XRE, xenobiotic response element; Nrf2, Nuclear factor erythroid 2-related factor 2; ARE, antioxidant response element; SOD2, superoxide dismutase 2; CAT, catalase; HO-1, Heme oxygenase-1; ROS, reactive oxygen species; Keap1, Kelch-like ECH-associated protein 1; β-TrCP, β-transduction repeat containing protein; Ub, ubiquitin
Publication
Fenofibrate attenuates the cytotoxic effect of cisplatin on lung cancer cells by enhancing the antioxidant defense system in vitro (2023) Mariko Kogami, et al. Oncol Lett. 2023 Jul;26(1). Figure: F8.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Homo sapiens | Primates | PPAR-a | PPAR-A | ncbigene_synonym | PPARA | 5465 |
| Homo sapiens | Primates | AhR | AHR | ncbigene_symbol | AHR | 196 |
| Homo sapiens | Primates | Nrf2 | NRF2 | ncbigene_synonym | GABPA | 2551 |
| Homo sapiens | Primates | Nrf2 | NRF2 | ncbigene_synonym | NFE2L2 | 4780 |
| Homo sapiens | Primates | HO-1, | HO-1 | ncbigene_synonym | HMOX1 | 3162 |
| Homo sapiens | Primates | SOD2, | SOD2 | ncbigene_symbol | SOD2 | 6648 |
| Homo sapiens | Primates | SOD2, | SOD2 | ncbigene_synonym | SOD2-OT1 | 100129518 |
| Homo sapiens | Primates | Keap1 | KEAP1 | ncbigene_symbol | KEAP1 | 9817 |
| Homo sapiens | Primates | B-TrCP | B-TRCP | ncbigene_synonym | BTRC | 8945 |
| Word | Match | MeSH | Name | ChEBI |
|---|---|---|---|---|
| Fenofibrate | Fenofibrate | propan-2-yl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate | chebi:5001 | |
| Nucleus | nucleus | nucleus | chebi:33252 | |
| ROS | ROS | chebi:26523 | ||
| Antioxidants | antioxidants | chebi:22586 | ||
| Cisplatin | cisplatin | (SP-4-2)-diamminedichloridoplatinum | chebi:27899 |
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|