Mettl3 Mediated m6A Methylation Involved in Epithelial-Mesenchymal Transition by Targeting SOCS3/STAT3/SNAI1 in Cigarette Smoking-Induced COPD

Schematic illustration of m6A modification involvement in IL-6/STAT3/SNAI1 pathway and EMT in HBEC exposed to CSE. Inhaled cigarette smoking is primarily targeted at the airway epithelial cells. The activation of IL-6/STAT3/SNAI1 signaling triggers EMT processes in airway epithelial cells. Mettl3 induced by cigarette smoking inhibits the negative regulatory effect of SOCS3 on IL-6/STAT3/SNAI1 signaling, as it reduces the protein expression of SOCS3 through m6A methylation, which contributes to airway remodeling in COPD.
Mettl3 Mediated m6A Methylation Involved in Epithelial-Mesenchymal Transition by Targeting SOCS3/STAT3/SNAI1 in Cigarette Smoking-Induced COPD
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Mettl3 Mediated m6A Methylation Involved in Epithelial-Mesenchymal Transition by Targeting SOCS3/STAT3/SNAI1 in Cigarette Smoking-Induced COPD. (2023) Yaping Zhang, et al. Int J Chron Obstruct Pulmon Dis. 2023;18:1007-1017. Figure: F5.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates IL6 IL6 ncbigene_symbol IL6 3569
Homo sapiens Primates IL6R IL6R ncbigene_symbol IL6R 3570
Homo sapiens Primates STAT3 STAT3 ncbigene_symbol STAT3 6774
Homo sapiens Primates SOCS3 SOCS3 ncbigene_symbol SOCS3 9021
Homo sapiens Primates M6A M6A ncbigene_synonym GPM6A 2823
Homo sapiens Primates M6A M6A ncbigene_synonym METTL3 56339
Homo sapiens Primates E-cadherin CDH1 ncbigene_symbol CDH1 999
Homo sapiens Primates E-cadherin CDH1 ncbigene_synonym FZR1 51343
Homo sapiens Primates EMT EMT ncbigene_synonym ITK 3702
Homo sapiens Primates EMT EMT ncbigene_synonym SLC22A3 6581

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID