CGRP cellular pathway

CGRP cellular pathway. CGRP transmits signals to the cell using the G protein-coupled receptor-CLR-RAMP1 dimer: 1. cAMP signaling pathway: activates the G protein and AC to increase the intracellular second messenger. cAMP concentration activates PKA and CREB and promotes mRNA transcription in the nucleus. 2. Phosphatidylinositol signaling pathway: by activating PLCβ1, hydrolyzing PIP2 to generate second messengers, IP3 and DAG. IP3 is gated with the IP3 ligand on the endoplasmic reticulum. Calcium channel binding elevates the intracellular Ca2+ concentration and activates various calcium ion-dependent proteins. DAG rivets on the cell membrane to activate PKC bound to the cell membrane. Moreover, intracellular free PKC can phosphorylate the serine/threonine residues of proteins and have a biological effect. AC is adenylate cyclase. cAMP is cyclic adenosine monophosphate, PKA is protein kinase A, CREB is cyclic adenosine monophosphate response element binding protein, PLCβ1 is the phospholipase C, β1, IP3 is inositol 1,4,5-triphosphate, DAG is the diacylglycerol, PIP2 is the phosphatidylinositol-4,5-bisphosphate, PKC is a protein kinase C, CGRP is a calcitonin gene-related peptide, CLR is a calcitonin gene-related Peptide receptor, RAMP1 is the receptor activity modifier protein 1, RCP is the receptor component protein, and ER is the endoplasmic reticulum

Publication

Research Progress in Calcitonin Gene-Related Peptide and Bone Repair (2023) Qichang Wang, et al. Biomolecules. 2023 May;13(5). Figure: F2. Homo sapiens

Disease mentions