Effects of RSV on activation of SIRT1 signalling pathway

The effects of RSV on activation of SIRT1 signalling pathway. The activation of the SIRT1-FoxO3a complex transcription in MSCs promote osteoblast differentiation while suppressing PPARγ and Sox9 to inhibit adipocyte and chondrocyte differentiation, respectively. Meanwhile, the transcriptional activity of SIRT1-FoxO increases SOD2 production to reduce ROS production and inhibits the NF-κB and signalling pathway, which favour osteoclastogenesis. Abbreviation: SIRT1: silent information regulator of transcription 1; FoxO: Forkhead box O; RunX2: runt-related transcription factor; PGC1α: peroxisome proliferator activated receptor gamma coactivator; ROS: Reactive Oxygen Species; SOD: Superoxide dismutase; NFATc1: nuclear factor-activated T cells; PPARγ: Peroxisome proliferator-activated receptors γ; NF-κB: Nuclear factor-κB; ALP: Alkaline phosphatase; Col1: Collagen type 1; OCN; Osteocalcin

Publication

Revisiting Resveratrol as an Osteoprotective Agent: Molecular Evidence from In Vivo and In Vitro Studies (2023) Haryati Ahmad Hairi, et al. Biomedicines. 2023 May;11(5). Figure: F2. Homo sapiens

Disease mentions