IL-36 signaling pathway

IL-36 signaling pathway. Neutrophil-derived proteases process and activate IL-36 cytokines. Activated IL-36 agonists bind IL-36R and recruit IL-1RAcP, which then relies on MyD88 to trigger downstream inflammatory signaling. This process is inhibited by IL-36Ra and IL-38. IL, interleukin; IL-36Ra, IL-36 receptor antagonist; MAPK, mitogen-activated protein kinase; TIR, MyD88; TRAF6, IRAK, IKK, AP-1.
IL-36 signaling pathway
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Publication

New insights on IL‑36 in intestinal inflammation and colorectal cancer (Review) (2023) Minghui Li, et al. Exp Ther Med. 2023 Jun;25(6). Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates MAPK MAPK famplex_relations MAPK1 5594
Homo sapiens Primates MAPK MAPK famplex_relations MAPK3 5595
Homo sapiens Primates MAPK MAPK famplex_relations MAPK11 5600
Homo sapiens Primates MAPK MAPK famplex_relations MAPK12 6300
Homo sapiens Primates MAPK MAPK famplex_relations MAPK13 5603
Homo sapiens Primates MAPK MAPK famplex_relations MAPK14 1432
Homo sapiens Primates MAPK MAPK famplex_relations MAPK8 5599
Homo sapiens Primates MAPK MAPK famplex_relations MAPK9 5601
Homo sapiens Primates MAPK MAPK famplex_relations MAPK10 5602
Homo sapiens Primates Cathepsin CATHEPSIN famplex_relations CTSA 5476
Homo sapiens Primates Cathepsin CATHEPSIN famplex_relations CTSB 1508
Homo sapiens Primates Cathepsin CATHEPSIN famplex_relations CTSC 1075
Homo sapiens Primates Cathepsin CATHEPSIN famplex_relations CTSD 1509
Homo sapiens Primates Cathepsin CATHEPSIN famplex_relations CTSE 1510
Homo sapiens Primates Cathepsin CATHEPSIN famplex_relations CTSF 8722
Homo sapiens Primates Cathepsin CATHEPSIN famplex_relations CTSG 1511
Homo sapiens Primates Cathepsin CATHEPSIN famplex_relations CTSH 1512
Homo sapiens Primates Cathepsin CATHEPSIN famplex_relations CTSK 1513
Homo sapiens Primates Cathepsin CATHEPSIN famplex_relations CTSL 1514
Homo sapiens Primates Cathepsin CATHEPSIN famplex_relations CTSO 1519
Homo sapiens Primates Cathepsin CATHEPSIN famplex_relations CTSS 1520
Homo sapiens Primates Cathepsin CATHEPSIN famplex_relations CTSV 1515
Homo sapiens Primates Cathepsin CATHEPSIN famplex_relations CTSW 1521
Homo sapiens Primates Cathepsin CATHEPSIN famplex_relations CTSZ 1522
Homo sapiens Primates IL-36a IL36A ncbigene_symbol IL36A 27179
Homo sapiens Primates IL-36Ra IL-36RA ncbigene_synonym IL36RN 26525
Homo sapiens Primates IL-38 IL-38 ncbigene_synonym IL1F10 84639
Homo sapiens Primates IL-36R IL-36R ncbigene_synonym IL1RL2 8808
Homo sapiens Primates IL-1RACP IL-1RACP ncbigene_synonym IL1RAP 3556
Homo sapiens Primates MyD88 MYD88 ncbigene_symbol MYD88 4615
Homo sapiens Primates TRAF6 TRAF6 ncbigene_symbol TRAF6 7189
Homo sapiens Primates IRAK IRAK ncbigene_synonym IRAK1 3654
Homo sapiens Primates IKK IKK famplex_relations CHUK 1147
Homo sapiens Primates IKK IKK famplex_relations IKBKB 3551
Homo sapiens Primates IKK IKK famplex_relations IKBKG 8517
Homo sapiens Primates IKK IKK famplex_relations IKBKE 9641
Homo sapiens Primates IKK IKK famplex_relations TBK1 29110
Homo sapiens Primates NF-kB NF-KB ncbigene_synonym NFKB1 4790

Chemical mentions

Word Match MeSH Name ChEBI
Nucleus nucleus nucleus chebi:33252

Disease mentions

Word Match MeSH Name DOID