Evolutionary chart of human molecular pathway of EGFR signaling (A), Notch (B), and Hedgehog (C) pathways

Evolutionary chart of human molecular pathway of EGFR signaling (A), Notch (B), and Hedgehog (C) pathways. Blue color intensity reflects NGREAGG value, size of nodes is proportionate to averaged dN/dS score. Nodes where dN/dS information is missing are given in rhombic shape. Nodes where no NGREAGG values are available are shown in yellow. A number in brackets stands if the node has the same name but a different number of molecular participants in different pathways under analysis
Evolutionary chart of human molecular pathway of EGFR signaling (A), Notch (B), and Hedgehog (C) pathways
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Publication

Distinct Traits of Structural and Regulatory Evolutional Conservation of Human Genes with Specific Focus on Major Cancer Molecular Pathways (2023) Galina Zakharova, et al. Cells. 2023 May;12(9). Figure: F7.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates Actin ACTIN famplex_relations ACTA1 58
Homo sapiens Primates Actin ACTIN famplex_relations ACTA2 59
Homo sapiens Primates Actin ACTIN famplex_relations ACTB 60
Homo sapiens Primates Actin ACTIN famplex_relations ACTC1 70
Homo sapiens Primates Actin ACTIN famplex_relations ACTG1 71
Homo sapiens Primates Actin ACTIN famplex_relations ACTG2 72
Homo sapiens Primates MAPK MAPK famplex_relations MAPK1 5594
Homo sapiens Primates MAPK MAPK famplex_relations MAPK3 5595
Homo sapiens Primates MAPK MAPK famplex_relations MAPK11 5600
Homo sapiens Primates MAPK MAPK famplex_relations MAPK12 6300
Homo sapiens Primates MAPK MAPK famplex_relations MAPK13 5603
Homo sapiens Primates MAPK MAPK famplex_relations MAPK14 1432
Homo sapiens Primates MAPK MAPK famplex_relations MAPK8 5599
Homo sapiens Primates MAPK MAPK famplex_relations MAPK9 5601
Homo sapiens Primates MAPK MAPK famplex_relations MAPK10 5602
Homo sapiens Primates PAK1 PAK1 ncbigene_symbol PAK1 5058
Homo sapiens Primates PAK1 PAK1 ncbigene_synonym PKN1 5585
Homo sapiens Primates MAP3K1 MAP3K1 ncbigene_symbol MAP3K1 4214
Homo sapiens Primates Rho RHO ncbigene_symbol RHO 6010
Homo sapiens Primates Rho RHO ncbigene_synonym RHOD 29984
Homo sapiens Primates Rho RHO famplex_relations RHOA 387
Homo sapiens Primates Rho RHO famplex_relations RHOB 388
Homo sapiens Primates Rho RHO famplex_relations RHOC 389
Homo sapiens Primates Nck NCK ncbigene_synonym NCK1 4690
Homo sapiens Primates C-Fos C-FOS ncbigene_synonym FOS 2353
Homo sapiens Primates Rac1 RAC1 ncbigene_symbol RAC1 5879
Homo sapiens Primates Rac1 RAC1 ncbigene_synonym RNASE1 6035
Homo sapiens Primates EGFR EGFR ncbigene_symbol EGFR 1956
Homo sapiens Primates MAP2K1/2/4/7 MAP2 ncbigene_symbol MAP2 4133
Homo sapiens Primates MAP2K1/2/4/7 MAP2 ncbigene_synonym MASP2 10747
Homo sapiens Primates MAP2K1/2/4/7 MAP2 ncbigene_synonym METAP2 10988
Homo sapiens Primates MAP2K1/2/4/7 MAP2 famplex_relations MAP4 4134
Homo sapiens Primates MAP2K1/2/4/7 MAP2 famplex_relations MAPT 4137
Homo sapiens Primates MAP2K1/2/4/7 MAP2K1 ncbigene_symbol MAP2K1 5604
Homo sapiens Primates MAP2K1/2/4/7 MAP7 ncbigene_symbol MAP7 9053
Homo sapiens Primates GAP GAP ncbigene_synonym RASA1 5921
Homo sapiens Primates GAP GAP ncbigene_synonym RGS6 9628
Homo sapiens Primates Cbl CBL ncbigene_symbol CBL 867
Homo sapiens Primates MLK2 MLK2 ncbigene_synonym MAP3K10 4294
Homo sapiens Primates GRB2 GRB2 ncbigene_symbol GRB2 2885
Homo sapiens Primates Raf RAF ncbigene_synonym ZHX2 22882
Homo sapiens Primates Raf RAF famplex_relations ARAF 369
Homo sapiens Primates Raf RAF famplex_relations BRAF 673
Homo sapiens Primates Raf RAF famplex_relations RAF1 5894
Homo sapiens Primates Elk1 ELK1 ncbigene_symbol ELK1 2002
Homo sapiens Primates Elk1 ELK1 ncbigene_synonym KCNH4 23415
Homo sapiens Primates Elk1 ELK1 ncbigene_synonym KCNH8 131096
Homo sapiens Primates SOS SOS ncbigene_synonym XYLT2 64132
Homo sapiens Primates SOS SOS famplex_relations SOS1 6654
Homo sapiens Primates SOS SOS famplex_relations SOS2 6655
Homo sapiens Primates Ras RAS famplex_relations KRAS 3845
Homo sapiens Primates Ras RAS famplex_relations HRAS 3265
Homo sapiens Primates Ras RAS famplex_relations NRAS 4893
Homo sapiens Primates SHO SHO ncbigene_synonym SPRN 503542
Homo sapiens Primates Dok2 DOK2 ncbigene_symbol DOK2 9046
Homo sapiens Primates Ctnn-Beta CTNNB ncbigene_synonym CTNNB1 1499
Homo sapiens Primates E3B1 E3B1 ncbigene_synonym ABI1 10006
Homo sapiens Primates E-Cadherin CDH1 ncbigene_symbol CDH1 999
Homo sapiens Primates E-Cadherin CDH1 ncbigene_synonym FZR1 51343
Homo sapiens Primates JAK1 JAK1 ncbigene_symbol JAK1 3716
Homo sapiens Primates JAK1/2 JAK2 ncbigene_symbol JAK2 3717
Homo sapiens Primates EGF EGF ncbigene_symbol EGF 1950
Homo sapiens Primates c-Myc C-MYC ncbigene_synonym MYC 4609
Homo sapiens Primates Src SRC ncbigene_symbol SRC 6714
Homo sapiens Primates Src SRC famplex_relations FGR 2268
Homo sapiens Primates Src SRC famplex_relations FYN 2534
Homo sapiens Primates Src SRC famplex_relations YES1 7525
Homo sapiens Primates PLC-Gamma PLCG famplex_relations PLCG1 5335
Homo sapiens Primates PLC-Gamma PLCG famplex_relations PLCG2 5336
Homo sapiens Primates NF-kappaB NF-KAPPAB ncbigene_synonym NFKB1 4790
Homo sapiens Primates PTK2 PTK2 ncbigene_symbol PTK2 5747
Homo sapiens Primates EPS8 EPS8 ncbigene_symbol EPS8 2059
Homo sapiens Primates Muc1 MUC1 ncbigene_symbol MUC1 4582
Homo sapiens Primates Csk CSK ncbigene_symbol CSK 1445
Homo sapiens Primates Her2 HER2 ncbigene_synonym ERBB2 2064
Homo sapiens Primates PDK1 PDK1 ncbigene_symbol PDK1 5163
Homo sapiens Primates PDK1 PDK1 ncbigene_synonym PDPK1 5170
Homo sapiens Primates GAB1 GAB1 ncbigene_symbol GAB1 2549
Homo sapiens Primates GAB1 GAB1 ncbigene_synonym PIGU 128869
Homo sapiens Primates Akt AKT ncbigene_synonym AKT1 207
Homo sapiens Primates Akt AKT famplex_relations AKT2 208
Homo sapiens Primates Akt AKT famplex_relations AKT3 10000
Homo sapiens Primates USP6NL USP6NL ncbigene_symbol USP6NL 9712
Homo sapiens Primates Rab5 RAB5 ncbigene_synonym RAB5A 5868
Homo sapiens Primates SKIP SKIP ncbigene_synonym SNW1 22938
Homo sapiens Primates SKIP SKIP ncbigene_synonym PLEKHM2 23207
Homo sapiens Primates SKIP SKIP ncbigene_synonym INPP5K 51763
Homo sapiens Primates SKIP SKIP ncbigene_synonym SPHKAP 80309
Homo sapiens Primates Gamma-secretase GAMMASECRETASE famplex_relations APH1A 51107
Homo sapiens Primates Gamma-secretase GAMMASECRETASE famplex_relations PSEN1 5663
Homo sapiens Primates Gamma-secretase GAMMASECRETASE famplex_relations PSENEN 55851
Homo sapiens Primates HAT HAT ncbigene_synonym TMPRSS11D 9407
Homo sapiens Primates G-Proteins GPROTEIN famplex_relations GNAO1 2775
Homo sapiens Primates G-Proteins GPROTEIN famplex_relations GNAI1 2770
Homo sapiens Primates G-Proteins GPROTEIN famplex_relations GNAI2 2771
Homo sapiens Primates G-Proteins GPROTEIN famplex_relations GNAI3 2773
Homo sapiens Primates G-Proteins GPROTEIN famplex_relations GNAT1 2779
Homo sapiens Primates G-Proteins GPROTEIN famplex_relations GNAT2 2780
Homo sapiens Primates G-Proteins GPROTEIN famplex_relations GNAT3 346562
Homo sapiens Primates G-Proteins GPROTEIN famplex_relations GNAZ 2781
Homo sapiens Primates G-Proteins GPROTEIN famplex_relations GNAS 2778
Homo sapiens Primates G-Proteins GPROTEIN famplex_relations GNAL 2774
Homo sapiens Primates G-Proteins GPROTEIN famplex_relations GNAQ 2776
Homo sapiens Primates G-Proteins GPROTEIN famplex_relations GNA11 2767
Homo sapiens Primates G-Proteins GPROTEIN famplex_relations GNA14 9630
Homo sapiens Primates G-Proteins GPROTEIN famplex_relations GNA15 2769
Homo sapiens Primates G-Proteins GPROTEIN famplex_relations GNA12 2768
Homo sapiens Primates G-Proteins GPROTEIN famplex_relations GNA13 10672
Homo sapiens Primates AC ADCY famplex_relations ADCY1 107
Homo sapiens Primates AC ADCY famplex_relations ADCY2 108
Homo sapiens Primates AC ADCY famplex_relations ADCY3 109
Homo sapiens Primates AC ADCY famplex_relations ADCY4 196883
Homo sapiens Primates AC ADCY famplex_relations ADCY5 111
Homo sapiens Primates AC ADCY famplex_relations ADCY6 112
Homo sapiens Primates AC ADCY famplex_relations ADCY7 113
Homo sapiens Primates AC ADCY famplex_relations ADCY8 114
Homo sapiens Primates AC ADCY famplex_relations ADCY9 115
Homo sapiens Primates AC ADCY famplex_relations ADCY10 55811
Homo sapiens Primates PKA PKA famplex_relations PRKAR1A 5573
Homo sapiens Primates PKA PKA famplex_relations PRKAR1B 5575
Homo sapiens Primates PKA PKA famplex_relations PRKAR2A 5576
Homo sapiens Primates PKA PKA famplex_relations PRKAR2B 5577
Homo sapiens Primates PKA PKA famplex_relations PRKACA 5566
Homo sapiens Primates PKA PKA famplex_relations PRKACB 5567
Homo sapiens Primates PKA PKA famplex_relations PRKACG 5568
Homo sapiens Primates Notch NOTCH famplex_relations NOTCH1 4851
Homo sapiens Primates Notch NOTCH famplex_relations NOTCH2 4853
Homo sapiens Primates Notch NOTCH famplex_relations NOTCH3 4854
Homo sapiens Primates Notch NOTCH famplex_relations NOTCH4 4855
Homo sapiens Primates Smo SMO ncbigene_symbol SMO 6608
Homo sapiens Primates Smo SMO ncbigene_synonym SMOX 54498
Homo sapiens Primates Glia GIIA ncbigene_synonym GANAB 23193
Homo sapiens Primates TACE TACE ncbigene_synonym ADAM17 6868
Homo sapiens Primates SMRT SMRT ncbigene_synonym NCOR2 9612
Homo sapiens Primates CSL CSL ncbigene_synonym CSHL1 1444
Homo sapiens Primates CSL CSL ncbigene_synonym RBPJ 3516
Homo sapiens Primates CSL CSL ncbigene_synonym SMPX 23676
Homo sapiens Primates CBP CBP ncbigene_synonym CREBBP 1387
Homo sapiens Primates CBP CBP ncbigene_synonym EIF4E 1977
Homo sapiens Primates CBP CBP ncbigene_synonym OPN1LW 5956
Homo sapiens Primates CBP CBP ncbigene_synonym PAG1 55824
Homo sapiens Primates CBP CBP ncbigene_synonym PCBP4 57060
Homo sapiens Primates WNT WNT famplex_relations WNT1 7471
Homo sapiens Primates WNT WNT famplex_relations WNT2 7472
Homo sapiens Primates WNT WNT famplex_relations WNT2B 7482
Homo sapiens Primates WNT WNT famplex_relations WNT3 7473
Homo sapiens Primates WNT WNT famplex_relations WNT3A 89780
Homo sapiens Primates WNT WNT famplex_relations WNT4 54361
Homo sapiens Primates WNT WNT famplex_relations WNT6 7475
Homo sapiens Primates WNT WNT famplex_relations WNT7A 7476
Homo sapiens Primates WNT WNT famplex_relations WNT7B 7477
Homo sapiens Primates WNT WNT famplex_relations WNT8A 7478
Homo sapiens Primates WNT WNT famplex_relations WNT8B 7479
Homo sapiens Primates WNT WNT famplex_relations WNT9A 7483
Homo sapiens Primates WNT WNT famplex_relations WNT9B 7484
Homo sapiens Primates WNT WNT famplex_relations WNT10A 80326
Homo sapiens Primates WNT WNT famplex_relations WNT10B 7480
Homo sapiens Primates WNT WNT famplex_relations WNT11 7481
Homo sapiens Primates WNT WNT famplex_relations WNT16 51384
Homo sapiens Primates WNT WNT famplex_relations WNT5A 7474
Homo sapiens Primates WNT WNT famplex_relations WNT5B 81029
Homo sapiens Primates SUFU SUFU ncbigene_symbol SUFU 51684
Homo sapiens Primates Ptc1 PTC1 ncbigene_synonym PTCH1 5727
Homo sapiens Primates Ptc1 PTC1 ncbigene_synonym CCDC6 8030
Homo sapiens Primates Ptc1/2 PTC2 ncbigene_synonym PTCH2 8643
Homo sapiens Primates BMP BMP famplex_relations BMP1 649
Homo sapiens Primates BMP BMP famplex_relations BMP2 650
Homo sapiens Primates BMP BMP famplex_relations BMP3 651
Homo sapiens Primates BMP BMP famplex_relations BMP4 652
Homo sapiens Primates BMP BMP famplex_relations BMP5 653
Homo sapiens Primates BMP BMP famplex_relations BMP6 654
Homo sapiens Primates BMP BMP famplex_relations BMP7 655
Homo sapiens Primates BMP BMP famplex_relations BMP8A 353500
Homo sapiens Primates BMP BMP famplex_relations BMP8B 656
Homo sapiens Primates BMP BMP famplex_relations BMP10 27302
Homo sapiens Primates BMP BMP famplex_relations BMP15 9210
Homo sapiens Primates BMP BMP famplex_relations GDF1 2657
Homo sapiens Primates BMP BMP famplex_relations GDF2 2658
Homo sapiens Primates BMP BMP famplex_relations GDF3 9573
Homo sapiens Primates BMP BMP famplex_relations GDF5 8200
Homo sapiens Primates BMP BMP famplex_relations GDF6 392255
Homo sapiens Primates BMP BMP famplex_relations GDF7 151449
Homo sapiens Primates Sel10 SEL10 ncbigene_synonym FBXW7 55294
Homo sapiens Primates Hhs HHS ncbigene_synonym GALNT3 2591
Homo sapiens Primates Hhs HHS ncbigene_synonym APCDD1 147495
Homo sapiens Primates Tubulin TUBULIN famplex_relations TUBD1 51174
Homo sapiens Primates Tubulin TUBULIN famplex_relations TUBE1 51175
Homo sapiens Primates Tubulin TUBULIN famplex_relations TUBA1A 7846
Homo sapiens Primates Tubulin TUBULIN famplex_relations TUBA1B 10376
Homo sapiens Primates Tubulin TUBULIN famplex_relations TUBA1C 84790
Homo sapiens Primates Tubulin TUBULIN famplex_relations TUBA3C 7278
Homo sapiens Primates Tubulin TUBULIN famplex_relations TUBA3D 113457
Homo sapiens Primates Tubulin TUBULIN famplex_relations TUBA3E 112714
Homo sapiens Primates Tubulin TUBULIN famplex_relations TUBA4A 7277
Homo sapiens Primates Tubulin TUBULIN famplex_relations TUBA8 51807
Homo sapiens Primates Tubulin TUBULIN famplex_relations TUBAL3 79861
Homo sapiens Primates Tubulin TUBULIN famplex_relations TUBB 203068
Homo sapiens Primates Tubulin TUBULIN famplex_relations TUBB1 81027
Homo sapiens Primates Tubulin TUBULIN famplex_relations TUBB2A 7280
Homo sapiens Primates Tubulin TUBULIN famplex_relations TUBB2B 347733
Homo sapiens Primates Tubulin TUBULIN famplex_relations TUBB3 10381
Homo sapiens Primates Tubulin TUBULIN famplex_relations TUBB4A 10382
Homo sapiens Primates Tubulin TUBULIN famplex_relations TUBB4B 10383
Homo sapiens Primates Tubulin TUBULIN famplex_relations TUBB6 84617
Homo sapiens Primates Tubulin TUBULIN famplex_relations TUBG1 7283
Homo sapiens Primates Tubulin TUBULIN famplex_relations TUBG2 27175

Chemical mentions

Word Match MeSH Name ChEBI
cun Cun copper chebi:30052
GAP GAP 2-hydroxy-3-oxopropyl dihydrogen phosphate chebi:17138
Cbl Cbl cob(III)alamin chebi:28911
Paxillin paxillin (2R,4bS,6aS,12bS,12cR,14aS)-4b-hydroxy-2-(2-hydroxypropan-2-yl)-12b,12c-dimethyl-5,6,6a,7,12,12b,12c,13,14,14a-decahydro-2H-chromeno[5',6':6,7]indeno[1,2-b]indol-3(4bH)-one chebi:34907
EGF EGF L-alpha-glutamylglycyl-L-phenylalanine chebi:140739
HAT HAt hydrogen astatide chebi:30418
BMP BMP chebi:60815
Hhs HHS chebi:88937

Disease mentions

Word Match MeSH Name DOID