NAE inhibitor MLN4924 has utility in the treatment of lung cancer

The NAE inhibitor MLN4924 has utility in the treatment of lung cancer. It may affect the formation of the TME and promote tumor cell death by regulating a variety of proteins and various signaling pathways, such as the HIF pathway and NF-κB pathway. MLN4924 may also be combined with certain drugs to make chemotherapy and radiotherapy more effective. TME, tumor microenvironment; HIF, hypoxia-inducible factor; DSB, double-strand break; NAE, NEDD8-activating enzyme; mTOR, mammalian target of rapamycin; MDM2, murine double minute 2; RBX1, ring-box 1; Cdt1, chromatin and DNA replication factor 1; NOXA, phorbol-12-myristate-13-acetate-induced protein 1; DR5, death receptor 5; PTX, paclitaxel; CRL, cullin-ring ligase.
NAE inhibitor MLN4924 has utility in the treatment of lung cancer
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Publication

Targeting neddylation as a novel approach to lung cancer treatment (Review) (2023) Zhaochun Tian, et al. Int J Oncol. 2023 May;62(5). Figure: F5.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates MLN MLN ncbigene_symbol MLN 4295
Homo sapiens Primates MLN MLN ncbigene_synonym MRLN 100507027
Homo sapiens Primates HIF HIF famplex_relations HIF1A 3091
Homo sapiens Primates HIF HIF famplex_relations EPAS1 2034
Homo sapiens Primates HIF HIF famplex_relations HIF3A 64344
Homo sapiens Primates HIF HIF famplex_relations ARNT 405
Homo sapiens Primates HIF HIF famplex_relations ARNT2 9915
Homo sapiens Primates HIF HIF famplex_relations BMAL1 406
Homo sapiens Primates NF-kB NF-KB ncbigene_synonym NFKB1 4790
Homo sapiens Primates CRL CRL ncbigene_synonym IL31RA 133396
Homo sapiens Primates UBE2F UBE2F ncbigene_symbol UBE2F 140739
Homo sapiens Primates mTOR MTOR ncbigene_symbol MTOR 2475
Homo sapiens Primates ↑NOXA NOXA ncbigene_synonym PMAIP1 5366
Homo sapiens Primates DR5 DR5 ncbigene_synonym TNFRSF10B 8795

Chemical mentions

Word Match MeSH Name ChEBI
CRL cRL cyclo(L-arginyl-L-leucyl) chebi:231492

Disease mentions

Word Match MeSH Name DOID