Targeting Wnt signaling pathway by the latest technologies
Targeting Wnt signaling pathway by the latest technologies. β-catenin targeted PROTACs (xStAx-VHL) recruits E3 ligase to β-catenin, inducing the degradation of β-catenin using the ubiquitin–proteasome system. Additionally, the molecular glue of β-catenin and its E3 ligase β-TrCP, NRX-252114, enhances the β-catenin degradation. ADCs (LGR5-mc-vc-PAB-MMAE, LRG5-NMs818, and PF-06647020) targeting LGR5- or PTK7-expressing Wnt responder cells bind to the target cells and release a cytotoxic drug to induce the cell death. ASO (LNA-modified ASO, β-catenin targeting ASO) binds to the target region of RNA and suppresses expression.
Publication
A New Wave of Targeting ‘Undruggable’ Wnt Signaling for Cancer Therapy: Challenges and Opportunities (2023) Woo-Jung Park, et al. Cells. 2023 Apr;12(8). Figure: F3.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT1 | 7471 |
| Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT2 | 7472 |
| Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT2B | 7482 |
| Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT3 | 7473 |
| Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT3A | 89780 |
| Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT4 | 54361 |
| Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT6 | 7475 |
| Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT7A | 7476 |
| Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT7B | 7477 |
| Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT8A | 7478 |
| Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT8B | 7479 |
| Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT9A | 7483 |
| Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT9B | 7484 |
| Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT10A | 80326 |
| Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT10B | 7480 |
| Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT11 | 7481 |
| Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT16 | 51384 |
| Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT5A | 7474 |
| Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT5B | 81029 |
| Homo sapiens | Primates | ADC | ADC | ncbigene_synonym | AZIN2 | 113451 |
| Homo sapiens | Primates | ADC | ADC | ncbigene_synonym | GADL1 | 339896 |
| Homo sapiens | Primates | LGR5 | LGR5 | ncbigene_symbol | LGR5 | 8549 |
| Homo sapiens | Primates | FZD7 | FZD7 | ncbigene_symbol | FZD7 | 8324 |
| Homo sapiens | Primates | LRP5 | LRP5 | ncbigene_symbol | LRP5 | 4041 |
| Homo sapiens | Primates | LRP5/6 | LRP6 | ncbigene_symbol | LRP6 | 4040 |
| Homo sapiens | Primates | DVL | DVL | ncbigene_synonym | DVL1 | 1855 |
| Homo sapiens | Primates | DVL | DVL | ncbigene_synonym | DVL1P1 | 8215 |
| Homo sapiens | Primates | DVL | DVL | famplex_relations | DVL2 | 1856 |
| Homo sapiens | Primates | DVL | DVL | famplex_relations | DVL3 | 1857 |
| Homo sapiens | Primates | ZNRF3 | ZNRF3 | ncbigene_symbol | ZNRF3 | 84133 |
| Homo sapiens | Primates | RNF43/ZNRF3 | RNF43 | ncbigene_symbol | RNF43 | 54894 |
| Homo sapiens | Primates | PTK7 | PTK7 | ncbigene_symbol | PTK7 | 5754 |
| Homo sapiens | Primates | AXIN | AXIN | ncbigene_synonym | AXIN1 | 8312 |
| Homo sapiens | Primates | AXIN | AXIN | famplex_relations | AXIN2 | 8313 |
| Homo sapiens | Primates | CK1 | CK1 | ncbigene_synonym | CSNK1A1 | 1452 |
| Homo sapiens | Primates | CK1 | CK1 | ncbigene_synonym | KRT1 | 3848 |
| Homo sapiens | Primates | CK1 | CK1 | ncbigene_synonym | CSNK1A1L | 122011 |
| Homo sapiens | Primates | GSK3ẞ | GSK3 | famplex_relations | GSK3A | 2931 |
| Homo sapiens | Primates | GSK3ẞ | GSK3 | famplex_relations | GSK3B | 2932 |
| Homo sapiens | Primates | APC | APC | ncbigene_symbol | APC | 324 |
| Homo sapiens | Primates | APC | APC | ncbigene_synonym | PROC | 5624 |
| Homo sapiens | Primates | B-TrCP | B-TRCP | ncbigene_synonym | BTRC | 8945 |
| Homo sapiens | Primates | B-Catenin | CTNNB1 | ncbigene_symbol | CTNNB1 | 1499 |
| Homo sapiens | Primates | -CateninCBP/p300 | P300 | ncbigene_synonym | EP300 | 2033 |
| Homo sapiens | Primates | TCF/LEF | TCF | ncbigene_synonym | HNF4A | 3172 |
| Word | Match | MeSH | Name | ChEBI |
|---|---|---|---|---|
| ADC | ADC | (3R,4R)-4-amino-3-[(1-carboxylatoethenyl)oxy]cyclohexa-1,5-diene-1-carboxylate | chebi:35181 | |
| ADC | ADC | (3R,4R)-4-amino-3-[(1-carboxylatoethenyl)oxy]cyclohexa-1,5-diene-1-carboxylate | chebi:35181 | |
| ADC | ADC | (3R,4R)-4-amino-3-[(1-carboxylatoethenyl)oxy]cyclohexa-1,5-diene-1-carboxylate | chebi:35181 | |
| ADC | ADC | (3R,4R)-4-amino-3-[(1-carboxylatoethenyl)oxy]cyclohexa-1,5-diene-1-carboxylate | chebi:35181 | |
| Nucleus | nucleus | nucleus | chebi:33252 |
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|---|---|---|---|
| Cancer | cancer | cancer | DOID:162 |