Pig heart and lung xenotransplantation: Present status
Genetic modifications designed to address mechanisms of xenograft injury: Examples of genetic modifications designed to prevent known xenograft injury (top) include Gal a 1-3Gal and 2 other carbohydrates (triple knockout, TKO) and expression of human complement pathway regulatory proteins (hCPRPs) and coagulation pathway regulatory proteins, eg, thrombomodulin and endothelial protein C receptor (bottom). Absence of carbohydrate antigens and expression of human complement and coagulation pathway regulatory molecules reduce endothelial activation and injury.
Publication
Pig heart and lung xenotransplantation: Present status. (2023) Ryan Chaban, et al. J Heart Lung Transplant. ;41(8):1014-1022. Figure: F1.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Homo sapiens | Primates | Gal | GAL | ncbigene_symbol | GAL | 51083 |
| Homo sapiens | Primates | Gal | GAL | ncbigene_synonym | GALP | 85569 |
| Homo sapiens | Primates | aPC | APC | ncbigene_symbol | APC | 324 |
| Homo sapiens | Primates | aPC | APC | ncbigene_synonym | PROC | 5624 |
| Homo sapiens | Primates | CD47 | CD47 | ncbigene_symbol | CD47 | 961 |
| Homo sapiens | Primates | SIRPa | SIRPA | ncbigene_symbol | SIRPA | 140885 |
| Homo sapiens | Primates | EPCR | EPCR | ncbigene_synonym | PROCR | 10544 |
| Homo sapiens | Primates | PAR-1 | PAR-1 | ncbigene_synonym | MARK2 | 2011 |
| Homo sapiens | Primates | PAR-1 | PAR-1 | ncbigene_synonym | F2R | 2149 |
| Homo sapiens | Primates | PAR-1 | PAR-1 | ncbigene_synonym | PWAR1 | 145624 |
| Homo sapiens | Primates | HLA-E | HLA-E | ncbigene_symbol | HLA-E | 3133 |
| Drosophila melanogaster | Invertebrates | Gal | GAL | ncbigene_symbol | Gal | 33839 |
| Drosophila melanogaster | Invertebrates | CHO | CHO | ncbigene_synonym | VhaAC39-1 | 31342 |
| Drosophila melanogaster | Invertebrates | pig | PIG | ncbigene_symbol | pig | 252326 |
| Drosophila melanogaster | Invertebrates | pig | PIG | ncbigene_synonym | CG15914 | 32542 |
| Drosophila melanogaster | Invertebrates | TKO | TKO | ncbigene_symbol | tko | 31228 |
| Drosophila melanogaster | Invertebrates | aPC | APC | ncbigene_symbol | Apc | 44642 |
| Drosophila melanogaster | Invertebrates | aPC | APC | ncbigene_synonym | Apc2 | 42871 |
| Drosophila melanogaster | Invertebrates | aPC | APC | ncbigene_synonym | Axn | 43565 |
| Drosophila melanogaster | Invertebrates | aPC | APC | ncbigene_synonym | Fs(3)Apc | 49116 |
| Drosophila melanogaster | Invertebrates | PAR-1 | PAR-1 | ncbigene_symbol | par-1 | 2768852 |
| Word | Match | MeSH | Name | ChEBI |
|---|---|---|---|---|
| CHO | NA | mesh:C587043 | ||
| PESO | NA |
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|