PD-1/PD-L1 pathway plays a role in immunosuppression

The PD-1/PD-L1 pathway plays a role in immunosuppression. PD-L1 is abnormally expressed on tumor cells and APCs in the tumor microenvironment. When PD-L1 interact with PD-1, PD-1 can recruit tyrosine phosphatase SHP2, inactivating CD28 and T cell receptor (TCR) function and signaling pathway: PI3K/PIP3/Akt or RAS/MEK/ERK, which decreases CD8+ T cell proliferation, survival, and cytokine production.
PD-1/PD-L1 pathway plays a role in immunosuppression
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Publication

Recent Advancement of PD-L1 Detection Technologies and Clinical Applications in the Era of Precision Cancer Therapy (2023) Yuanfeng Zhang, et al. J Cancer. 2023;14(5). Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates ERK ERK ncbigene_synonym EPHB2 2048
Homo sapiens Primates ERK ERK ncbigene_synonym MAPK1 5594
Homo sapiens Primates ERK ERK famplex_relations MAPK3 5595
Homo sapiens Primates PD-L1 PD-L1 ncbigene_synonym CD274 29126
Homo sapiens Primates PD-1 PD-1 ncbigene_synonym PDCD1 5133
Homo sapiens Primates PD-1 PD-1 ncbigene_synonym RPL17 6139
Homo sapiens Primates PD-1 PD-1 ncbigene_synonym RPL17-C18orf32 100526842
Homo sapiens Primates RAS RAS famplex_relations KRAS 3845
Homo sapiens Primates RAS RAS famplex_relations HRAS 3265
Homo sapiens Primates RAS RAS famplex_relations NRAS 4893
Homo sapiens Primates MEK MEK ncbigene_synonym MAP2K7 5609
Homo sapiens Primates MEK MEK famplex_relations MAP2K1 5604
Homo sapiens Primates MEK MEK famplex_relations MAP2K2 5605
Homo sapiens Primates SHP2 SHP2 ncbigene_synonym PTPN11 5781
Homo sapiens Primates MHC MHC ncbigene_synonym HLA-C 3107
Homo sapiens Primates TCR TCR ncbigene_synonym TRBV20OR9-2 6962
Homo sapiens Primates TCR TCR famplex_relations TRA 6955
Homo sapiens Primates TCR TCR famplex_relations TRB 6957
Homo sapiens Primates TCR TCR famplex_relations TRD 6964
Homo sapiens Primates TCR TCR famplex_relations TRG 6965
Homo sapiens Primates LAT LAT ncbigene_symbol LAT 27040
Homo sapiens Primates LAT LAT ncbigene_synonym ORC3 23595
Homo sapiens Primates LAT LAT ncbigene_synonym SPNS1 83985
Homo sapiens Primates Zap70 ZAP70 ncbigene_symbol ZAP70 7535
Homo sapiens Primates PTEN PTEN ncbigene_symbol PTEN 5728
Homo sapiens Primates Akt AKT ncbigene_synonym AKT1 207
Homo sapiens Primates Akt AKT famplex_relations AKT2 208
Homo sapiens Primates Akt AKT famplex_relations AKT3 10000
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates CTLA-4 CTLA-4 ncbigene_synonym CTLA4 1493
Homo sapiens Primates CD28 CD28 ncbigene_symbol CD28 940
Homo sapiens Primates APC APC ncbigene_symbol APC 324
Homo sapiens Primates APC APC ncbigene_synonym PROC 5624

Chemical mentions

Word Match MeSH Name ChEBI
RAS RAS (1R)-N-(prop-2-yn-1-yl)indan-1-amine chebi:63620
MEK MEK butan-2-one chebi:28398

Disease mentions

Word Match MeSH Name DOID