Posttranslational modification in the cGAS-STING pathway

Mitochondrial stress induces the release of mtDNA and subsequently activates the cGAS-STING pathway. This signaling pathway can be regulated by various posttranslational modifications and can also be suppressed by caspases during apoptosis.
Posttranslational modification in the cGAS-STING pathway
Download JPG
View figure at PMC Read paper at PMC
PMC

Publication

Molecular mechanisms of mitochondrial DNA release and activation of the cGAS-STING pathway. (2023) Jeonghan Kim, et al. Exp Mol Med. 2023 Mar 24 :1-10. Figure: F5.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates AKT, AKT ncbigene_synonym AKT1 207
Homo sapiens Primates AKT, AKT famplex_relations AKT2 208
Homo sapiens Primates AKT, AKT famplex_relations AKT3 10000
Homo sapiens Primates -AKT,DNA-PK,AurB,PPP6c PPP6C ncbigene_symbol PPP6C 5537
Homo sapiens Primates -AKT,DNA-PK,AurB,PPP6c AURB ncbigene_synonym AURKB 9212
Homo sapiens Primates DNA-PK, DNAPK ncbigene_synonym PRKDC 5591
Homo sapiens Primates -TTLL4,TTLL6 TTLL6 ncbigene_symbol TTLL6 284076
Homo sapiens Primates TTLL4, TTLL4 ncbigene_symbol TTLL4 9654
Homo sapiens Primates TRIM38, TRIM38 ncbigene_symbol TRIM38 10475
Homo sapiens Primates RNF RNF ncbigene_synonym TRIM31 11074
Homo sapiens Primates SENP2, SENP2 ncbigene_symbol SENP2 59343
Homo sapiens Primates SENP2, SENP2 ncbigene_synonym SUMO1 7341
Homo sapiens Primates TRIM14,TRIM38,SENP2,RNF185 RNF185 ncbigene_symbol RNF185 91445
Homo sapiens Primates TRIM14,TRIM38,SENP2,RNF185 TRIM14 ncbigene_symbol TRIM14 9830
Homo sapiens Primates APO APO ncbigene_synonym AOPEP 84909
Homo sapiens Primates CGAS CGAS ncbigene_symbol CGAS 115004
Homo sapiens Primates -TRIM13,TRIM29,TRIM30,TRIM32, TRIM32 ncbigene_symbol TRIM32 22954
Homo sapiens Primates -TRIM13,TRIM29,TRIM30,TRIM32, TRIM29 ncbigene_symbol TRIM29 23650
Homo sapiens Primates TRIM13, TRIM13 ncbigene_symbol TRIM13 10206
Homo sapiens Primates RNF90, RNF90 ncbigene_synonym TRIM7 81786
Homo sapiens Primates RNF26, RNF26 ncbigene_symbol RNF26 79102
Homo sapiens Primates TRIM56, TRIM56 ncbigene_symbol TRIM56 81844
Homo sapiens Primates RNF5, RNF5 ncbigene_symbol RNF5 6048
Homo sapiens Primates MUL1 MUL1 ncbigene_symbol MUL1 79594
Homo sapiens Primates RNF115,AMFR,MUL1 AMFR ncbigene_symbol AMFR 267
Homo sapiens Primates RNF115,AMFR,MUL1 RNF115 ncbigene_symbol RNF115 27246
Homo sapiens Primates Caspases CASPASE famplex_relations CASP1 834
Homo sapiens Primates Caspases CASPASE famplex_relations CASP2 835
Homo sapiens Primates Caspases CASPASE famplex_relations CASP4 837
Homo sapiens Primates Caspases CASPASE famplex_relations CASP5 838
Homo sapiens Primates Caspases CASPASE famplex_relations CASP6 839
Homo sapiens Primates Caspases CASPASE famplex_relations CASP8 841
Homo sapiens Primates Caspases CASPASE famplex_relations CASP9 842
Homo sapiens Primates Caspases CASPASE famplex_relations CASP10 843
Homo sapiens Primates Caspases CASPASE famplex_relations CASP12 100506742
Homo sapiens Primates Caspases CASPASE famplex_relations CASP14 23581
Homo sapiens Primates Caspases CASPASE famplex_relations CASP3 836
Homo sapiens Primates Caspases CASPASE famplex_relations CASP7 840
Homo sapiens Primates STING STING ncbigene_synonym STING1 340061
Homo sapiens Primates TBK1 TBK1 ncbigene_symbol TBK1 29110
Homo sapiens Primates IRF3 IRF3 ncbigene_symbol IRF3 3661

Chemical mentions

Word Match MeSH Name ChEBI
AurB NA mesh:C001666

Disease mentions

Word Match MeSH Name DOID