Extracellular matrix stiffness—The central cue for skin fibrosis

Integrin, Hippo and TGF-β signaling pathways mediate mechanical stress signaling to the cell. (A) TGF-β is secreted out of cells in an inactive form. Activated TGF-β can upregulate ECM stiffness through fibroblast activation. (B) Mechanical signals are involved in TGF-β activation.The interaction of activated TGF-β and TGFBR mediated the transmembrane transduction of ECM mechanical signals, which is transduced via two pathways, Smad and non-Smad, thereby regulating myofibroblast differentiation and the stiffness of the ECM. Integrins can signal through pathways such as FAK, ILK and Hippo, and there is crosstalk with the TGF-β pathway.
Extracellular matrix stiffness—The central cue for skin fibrosis
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Extracellular matrix stiffness—The central cue for skin fibrosis. (2023) Kang Wang, et al. Front Mol Biosci. 2023;10:1132353. Figure: F5.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Drosophila melanogaster Invertebrates TGF-B TGF-B ncbigene_synonym dpp 33432
Drosophila melanogaster Invertebrates TGF-B TGF-B ncbigene_synonym gbb 37778
Drosophila melanogaster Invertebrates TGF-B TGF-B ncbigene_synonym put 41772
Drosophila melanogaster Invertebrates TGF-B TGF-B ncbigene_synonym mav 43804
Drosophila melanogaster Invertebrates SE SE ncbigene_symbol se 38973
Drosophila melanogaster Invertebrates (SLC) SLC ncbigene_symbol slc 44535
Drosophila melanogaster Invertebrates LAP LAP ncbigene_symbol lap 40863
Drosophila melanogaster Invertebrates LAP LAP ncbigene_synonym Lap-A 5656943
Drosophila melanogaster Invertebrates integrin INTEGRIN ncbigene_synonym scb 36692
Drosophila melanogaster Invertebrates Smad SMAD ncbigene_synonym Smox 31738
Drosophila melanogaster Invertebrates Smad SMAD ncbigene_synonym Mad 33529
Drosophila melanogaster Invertebrates St ST ncbigene_symbol st 39836
Drosophila melanogaster Invertebrates RAS RAS ncbigene_symbol ras 43873
Drosophila melanogaster Invertebrates RAS RAS ncbigene_synonym Ras64B 38494
Drosophila melanogaster Invertebrates RAS RAS ncbigene_synonym Ras85D 41140
Drosophila melanogaster Invertebrates RAF RAF ncbigene_symbol Raf 31221
Drosophila melanogaster Invertebrates ERK ERK ncbigene_synonym Erk7 31877
Drosophila melanogaster Invertebrates ERK ERK ncbigene_synonym rl 3354888
Drosophila melanogaster Invertebrates SOS SOS ncbigene_symbol Sos 34790
Drosophila melanogaster Invertebrates Grb2 GRB2 ncbigene_synonym drk 36497
Drosophila melanogaster Invertebrates MTOR MTOR ncbigene_symbol Mtor 36264
Drosophila melanogaster Invertebrates MTOR MTOR ncbigene_synonym Tor 47396
Drosophila melanogaster Invertebrates Src SRC ncbigene_synonym Src42A 35524
Drosophila melanogaster Invertebrates Src SRC ncbigene_synonym Csk 41398
Drosophila melanogaster Invertebrates Src SRC ncbigene_synonym Src64B 48973
Drosophila melanogaster Invertebrates FAK FAK ncbigene_symbol Fak 37233
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K21B 33203
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K59F 37733
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K68D 39329
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K92E 42446
Drosophila melanogaster Invertebrates AKT AKT ncbigene_symbol Akt 41957
Drosophila melanogaster Invertebrates S6K S6K ncbigene_symbol S6k 38654
Drosophila melanogaster Invertebrates Filamin FILAMIN ncbigene_synonym cher 42066
Drosophila melanogaster Invertebrates Talin TALIN ncbigene_synonym rhea 38978
Drosophila melanogaster Invertebrates TRAF4/6Ub)Rho TRAF4 ncbigene_symbol Traf4 33638
Drosophila melanogaster Invertebrates Rho RHO ncbigene_symbol rho 38168
Drosophila melanogaster Invertebrates Rho RHO ncbigene_synonym Bx 32846
Drosophila melanogaster Invertebrates Rho RHO ncbigene_synonym Rho1 36775
Drosophila melanogaster Invertebrates Rho RHO ncbigene_synonym Lcp65Ab1 48382
Drosophila melanogaster Invertebrates IKK IKK ncbigene_synonym IKKepsilon 35329
Drosophila melanogaster Invertebrates IKK IKK ncbigene_synonym key 37967
Drosophila melanogaster Invertebrates IKK IKK ncbigene_synonym IKKbeta 44432
Drosophila melanogaster Invertebrates ILK ILK ncbigene_symbol Ilk 53573
Drosophila melanogaster Invertebrates TAK1 TAK1 ncbigene_symbol Tak1 39659
Drosophila melanogaster Invertebrates UNK UNK ncbigene_symbol unk 42738
Drosophila melanogaster Invertebrates NF-KB NF-KB ncbigene_synonym Dif 35045
Drosophila melanogaster Invertebrates NF-KB NF-KB ncbigene_synonym dl 35047
Drosophila melanogaster Invertebrates NF-KB NF-KB ncbigene_synonym Rel 41087
Drosophila melanogaster Invertebrates YAP/TAZ YAP/TAZ ncbigene_synonym yki 37851
Drosophila melanogaster Invertebrates TAZ TAZ ncbigene_symbol Taz 36405
Drosophila melanogaster Invertebrates TAZ TAZ ncbigene_synonym Dis3 42900
Drosophila melanogaster Invertebrates LATS1 LATS1 ncbigene_synonym wts 43651
Drosophila melanogaster Invertebrates Actin ACTIN ncbigene_synonym Act5C 31521
Drosophila melanogaster Invertebrates Actin ACTIN ncbigene_synonym Act42A 35526
Drosophila melanogaster Invertebrates Actin ACTIN ncbigene_synonym Act57B 37368
Drosophila melanogaster Invertebrates Actin ACTIN ncbigene_synonym Act79B 40444
Drosophila melanogaster Invertebrates Actin ACTIN ncbigene_synonym Act88F 41885
Drosophila melanogaster Invertebrates Actin ACTIN ncbigene_synonym Act87E 48632
Drosophila melanogaster Invertebrates (ROCK ROCK ncbigene_synonym Rok 43916
Homo sapiens Primates TGFBR3 TGFBR3 ncbigene_symbol TGFBR3 7049
Homo sapiens Primates TGF-B TGFB ncbigene_synonym TGFB1 7040
Homo sapiens Primates TGF-B TGFB famplex_relations TGFB2 7042
Homo sapiens Primates TGF-B TGFB famplex_relations TGFB3 7043
Homo sapiens Primates Large LARGE ncbigene_synonym LARGE1 9215
Homo sapiens Primates (SLC) SLC ncbigene_synonym CCL21 6366
Homo sapiens Primates LAP LAP ncbigene_symbol LAP 7939
Homo sapiens Primates LAP LAP ncbigene_synonym ACP2 53
Homo sapiens Primates LAP LAP ncbigene_synonym PICALM 8301
Homo sapiens Primates LAP LAP ncbigene_synonym LAP3 51056
Homo sapiens Primates LAP LAP ncbigene_synonym CENPJ 55835
Homo sapiens Primates LAP LAP ncbigene_synonym PDON2 406237
Homo sapiens Primates TGFBR2 TGFBR2 ncbigene_symbol TGFBR2 7048
Homo sapiens Primates TGFBR1 TGFBR1 ncbigene_symbol TGFBR1 7046
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL6A1 1291
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL6A2 1292
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL6A3 1293
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL6A5 256076
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL6A6 131873
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL7A1 1294
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL8A1 1295
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL8A2 1296
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL9A1 1297
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL9A2 1298
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL9A3 1299
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL10A1 1300
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL11A1 1301
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL11A2 1302
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL12A1 1303
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL13A1 1305
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL14A1 7373
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL15A1 1306
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL16A1 1307
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL17A1 1308
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL18A1 80781
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL19A1 1310
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL20A1 57642
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL21A1 81578
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL22A1 169044
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL23A1 91522
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL24A1 255631
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL25A1 84570
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL26A1 136227
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL27A1 85301
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL28A1 340267
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL1A1 1277
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL1A2 1278
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL4A1 1282
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL4A2 1284
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL4A3 1285
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL4A4 1286
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL4A5 1287
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL4A6 1288
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL5A1 1289
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL5A2 1290
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL5A3 50509
Homo sapiens Primates Smad SMAD famplex_relations SMAD1 4086
Homo sapiens Primates Smad SMAD famplex_relations SMAD4 4089
Homo sapiens Primates Smad SMAD famplex_relations SMAD5 4090
Homo sapiens Primates Smad SMAD famplex_relations SMAD6 4091
Homo sapiens Primates Smad SMAD famplex_relations SMAD7 4092
Homo sapiens Primates Smad SMAD famplex_relations SMAD9 4093
Homo sapiens Primates Smad SMAD famplex_relations SMAD2 4087
Homo sapiens Primates Smad SMAD famplex_relations SMAD3 4088
Homo sapiens Primates RAS RAS famplex_relations KRAS 3845
Homo sapiens Primates RAS RAS famplex_relations HRAS 3265
Homo sapiens Primates RAS RAS famplex_relations NRAS 4893
Homo sapiens Primates SPSB1 SPSB1 ncbigene_symbol SPSB1 80176
Homo sapiens Primates RAF RAF ncbigene_synonym ZHX2 22882
Homo sapiens Primates RAF RAF famplex_relations ARAF 369
Homo sapiens Primates RAF RAF famplex_relations BRAF 673
Homo sapiens Primates RAF RAF famplex_relations RAF1 5894
Homo sapiens Primates ERK ERK ncbigene_synonym EPHB2 2048
Homo sapiens Primates ERK ERK ncbigene_synonym MAPK1 5594
Homo sapiens Primates ERK ERK famplex_relations MAPK3 5595
Homo sapiens Primates SOS SOS ncbigene_synonym XYLT2 64132
Homo sapiens Primates SOS SOS famplex_relations SOS1 6654
Homo sapiens Primates SOS SOS famplex_relations SOS2 6655
Homo sapiens Primates Grb2 GRB2 ncbigene_symbol GRB2 2885
Homo sapiens Primates MTOR MTOR ncbigene_symbol MTOR 2475
Homo sapiens Primates Src SRC ncbigene_symbol SRC 6714
Homo sapiens Primates Src SRC famplex_relations FGR 2268
Homo sapiens Primates Src SRC famplex_relations FYN 2534
Homo sapiens Primates Src SRC famplex_relations YES1 7525
Homo sapiens Primates FAK FAK ncbigene_synonym PTK2 5747
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates AKT AKT ncbigene_synonym AKT1 207
Homo sapiens Primates AKT AKT famplex_relations AKT2 208
Homo sapiens Primates AKT AKT famplex_relations AKT3 10000
Homo sapiens Primates S6K S6K ncbigene_synonym RPS6KB1 6198
Homo sapiens Primates TRAF4/6Ub)Rho TRAF4 ncbigene_symbol TRAF4 9618
Homo sapiens Primates Rho RHO ncbigene_symbol RHO 6010
Homo sapiens Primates Rho RHO ncbigene_synonym RHOD 29984
Homo sapiens Primates Rho RHO famplex_relations RHOA 387
Homo sapiens Primates Rho RHO famplex_relations RHOB 388
Homo sapiens Primates Rho RHO famplex_relations RHOC 389
Homo sapiens Primates IKK IKK famplex_relations CHUK 1147
Homo sapiens Primates IKK IKK famplex_relations IKBKB 3551
Homo sapiens Primates IKK IKK famplex_relations IKBKG 8517
Homo sapiens Primates IKK IKK famplex_relations IKBKE 9641
Homo sapiens Primates IKK IKK famplex_relations TBK1 29110
Homo sapiens Primates PARVA PARVA ncbigene_symbol PARVA 55742
Homo sapiens Primates ILK ILK ncbigene_symbol ILK 3611
Homo sapiens Primates TAK1 TAK1 ncbigene_synonym MAP3K7 6885
Homo sapiens Primates TAK1 TAK1 ncbigene_synonym NR2C2 7182
Homo sapiens Primates UNK UNK ncbigene_symbol UNK 85451
Homo sapiens Primates NF-KB NF-KB ncbigene_synonym NFKB1 4790
Homo sapiens Primates YAP/TAZ YAP ncbigene_synonym YAP1 10413
Homo sapiens Primates YAP/TAZ TAZ ncbigene_synonym TAFAZZIN 6901
Homo sapiens Primates YAP/TAZ TAZ ncbigene_synonym WWTR1 25937
Homo sapiens Primates LATS1 LATS1 ncbigene_symbol LATS1 9113
Homo sapiens Primates LATS1/2 LATS2 ncbigene_symbol LATS2 26524
Homo sapiens Primates Actin ACTIN famplex_relations ACTA1 58
Homo sapiens Primates Actin ACTIN famplex_relations ACTA2 59
Homo sapiens Primates Actin ACTIN famplex_relations ACTB 60
Homo sapiens Primates Actin ACTIN famplex_relations ACTC1 70
Homo sapiens Primates Actin ACTIN famplex_relations ACTG1 71
Homo sapiens Primates Actin ACTIN famplex_relations ACTG2 72
Homo sapiens Primates (ROCK ROCK famplex_relations ROCK1 6093
Homo sapiens Primates (ROCK ROCK famplex_relations ROCK2 9475

Chemical mentions

Word Match MeSH Name ChEBI
Co NA mesh:C065987

Disease mentions

Word Match MeSH Name DOID
SE NA