Metabolic regulation of dendritic cell activation and immune function during inflammation

Principal metabolic reprogramming pathways after DCs activation. (A) TBK1-IKKε-Akt-HK2 signaling regulates the short-term (minutes to hours following TLR ligation) metabolic regulation in DCs, which undergo rapid metabolic reprogramming. This signaling pathway stimulates glycolysis, which in turn supports other metabolic processes, such as fatty acid synthesis (FAS) and lipid synthesis, hence facilitating DC activation. (B) In the later stage of DCs activation, iNOS-dependent glycolysis was performed. TLR ligation triggers PI3K/AKT, and mTOR-HIF1α pathways to promote glycolysis, whereas iNOS-NO suppresses OXPHOS. While activated cDCs do not undergo iNOS-dependent glycolysis in vivo, autocrine type-I IFN signaling triggers HIF-1α-mediated glycolytic reprogramming Biorender.com.
Metabolic regulation of dendritic cell activation and immune function during inflammation
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Metabolic regulation of dendritic cell activation and immune function during inflammation. (2023) Lili Wu, et al. Front Immunol. 2023;14:1140749. Figure: F4.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates TLR TLR famplex_relations TLR1 7096
Homo sapiens Primates TLR TLR famplex_relations TLR2 7097
Homo sapiens Primates TLR TLR famplex_relations TLR3 7098
Homo sapiens Primates TLR TLR famplex_relations TLR4 7099
Homo sapiens Primates TLR TLR famplex_relations TLR5 7100
Homo sapiens Primates TLR TLR famplex_relations TLR6 10333
Homo sapiens Primates TLR TLR famplex_relations TLR7 51284
Homo sapiens Primates TLR TLR famplex_relations TLR8 51311
Homo sapiens Primates TLR TLR famplex_relations TLR9 54106
Homo sapiens Primates TLR TLR famplex_relations TLR10 81793
Homo sapiens Primates IKKE IKKE ncbigene_synonym IKBKE 9641
Homo sapiens Primates TBK1 TBK1 ncbigene_symbol TBK1 29110
Homo sapiens Primates AKT AKT ncbigene_synonym AKT1 207
Homo sapiens Primates AKT AKT famplex_relations AKT2 208
Homo sapiens Primates AKT AKT famplex_relations AKT3 10000
Homo sapiens Primates HK2 HK2 ncbigene_symbol HK2 3099
Homo sapiens Primates HK2 HK2 ncbigene_synonym KCNA5 3741
Homo sapiens Primates HK2 HK2 ncbigene_synonym KIF2A 3796
Homo sapiens Primates HK2 HK2 ncbigene_synonym KLK2 3817
Homo sapiens Primates HK2 HK2 ncbigene_synonym HOOK2 29911
Homo sapiens Primates FAS FAS ncbigene_symbol FAS 355
Homo sapiens Primates FAS FAS ncbigene_synonym FASN 2194
Homo sapiens Primates GLUT GLUT ncbigene_synonym SLC2A1 6513
Homo sapiens Primates IFN IFN ncbigene_synonym IFNA1 3439
Homo sapiens Primates IFNAR IFNAR ncbigene_synonym IFNAR1 3454
Homo sapiens Primates IFNAR IFNAR famplex_relations IFNAR2 3455
Homo sapiens Primates P13K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates P13K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates P13K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates P13K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates P13K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates P13K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates P13K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates P13K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates P13K PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates P13K PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates MTOR MTOR ncbigene_symbol MTOR 2475
Mus musculus Rodents IKKE IKKE ncbigene_synonym Ikbke 56489
Mus musculus Rodents TBK1 TBK1 ncbigene_symbol Tbk1 56480
Mus musculus Rodents AKT AKT ncbigene_synonym Akt1 11651
Mus musculus Rodents HK2 HK2 ncbigene_symbol Hk2 15277
Mus musculus Rodents TCA TCA ncbigene_synonym Gnat2 14686
Mus musculus Rodents FAS FAS ncbigene_symbol Fas 14102
Mus musculus Rodents FAS FAS ncbigene_synonym Fasn 14104
Mus musculus Rodents GLUT GLUT ncbigene_synonym Slc1a3 20512
Mus musculus Rodents IFNAR IFNAR ncbigene_synonym Ifnar1 15975
Mus musculus Rodents P13K PI3K ncbigene_synonym Pik3r1 18708
Mus musculus Rodents MTOR MTOR ncbigene_symbol Mtor 56717
Drosophila melanogaster Invertebrates TLR TLR ncbigene_synonym 18w 37277
Drosophila melanogaster Invertebrates TLR TLR ncbigene_synonym tok 42944
Drosophila melanogaster Invertebrates TLR TLR ncbigene_synonym tlr-2 44349
Drosophila melanogaster Invertebrates IKKE IKKE ncbigene_symbol IKKepsilon 35329
Drosophila melanogaster Invertebrates AKT AKT ncbigene_symbol Akt 41957
Drosophila melanogaster Invertebrates cycle CYCLE ncbigene_synonym CycE 34924
Drosophila melanogaster Invertebrates cycle CYCLE ncbigene_synonym cyc 40162
Drosophila melanogaster Invertebrates FAS FAS ncbigene_synonym Fas2 31364
Drosophila melanogaster Invertebrates FAS FAS ncbigene_synonym FASN1 33524
Drosophila melanogaster Invertebrates FAS FAS ncbigene_synonym Fas3 35097
Drosophila melanogaster Invertebrates FAS FAS ncbigene_synonym fand 36514
Drosophila melanogaster Invertebrates FAS FAS ncbigene_synonym tei 36521
Drosophila melanogaster Invertebrates FAS FAS ncbigene_synonym rg 44531
Drosophila melanogaster Invertebrates FAS FAS ncbigene_synonym FASN2 117361
Drosophila melanogaster Invertebrates FAS FAS ncbigene_synonym FASN3 3355111
Drosophila melanogaster Invertebrates GLUT GLUT ncbigene_synonym Eaat1 34251
Drosophila melanogaster Invertebrates GLUT GLUT ncbigene_synonym Glut1 38109
Drosophila melanogaster Invertebrates GLUT GLUT ncbigene_synonym Glut4EF 41217
Drosophila melanogaster Invertebrates GLUT GLUT ncbigene_synonym Glut3 42036
Drosophila melanogaster Invertebrates P13K PI3K ncbigene_synonym Pi3K21B 33203
Drosophila melanogaster Invertebrates P13K PI3K ncbigene_synonym Pi3K59F 37733
Drosophila melanogaster Invertebrates P13K PI3K ncbigene_synonym Pi3K68D 39329
Drosophila melanogaster Invertebrates P13K PI3K ncbigene_synonym Pi3K92E 42446
Drosophila melanogaster Invertebrates MTOR MTOR ncbigene_symbol Mtor 36264
Drosophila melanogaster Invertebrates MTOR MTOR ncbigene_synonym Tor 47396
Drosophila melanogaster Invertebrates on ON ncbigene_symbol On 252296
Danio rerio Vertebrates TBK1 TBK1 ncbigene_symbol tbk1 692289
Danio rerio Vertebrates HK2 HK2 ncbigene_symbol hk2 406339
Danio rerio Vertebrates FAS FAS ncbigene_symbol fas 768248
Danio rerio Vertebrates IFN IFN ncbigene_synonym ifnphi1 360134
Danio rerio Vertebrates MTOR MTOR ncbigene_symbol mtor 324254

Chemical mentions

Word Match MeSH Name ChEBI
Glucose Glucose mesh:D005947 D-glucopyranose chebi:4167
TCA NA mesh:C000589078
Pyruvate Lactate NA mesh:D019344
NO NA

Disease mentions

Word Match MeSH Name DOID